33092-86-3

Basic information

• Product Name: trans-2-aminocyclopentanol
• Synonyms: trans-2-aminocyclopentanol
• CAS NO: 33092-86-3
• Molecular Weight: 101.148
• Mol File: 33092-86-3.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: trans-2-aminocyclopentanol(CAS DataBase Reference)
• NIST Chemistry Reference: trans-2-aminocyclopentanol(33092-86-3)
• EPA Substance Registry System: trans-2-aminocyclopentanol(33092-86-3)

Safety Data

• Hazardous Substances Data: 33092-86-3(Hazardous Substances Data)

Upstream product

• 198422-71-8 benzyl (1S,2S)-trans-N-(2-hydroxycyclopentyl)carbamate 
• 181657-56-7 (1S,2S)-2-(benzyloxy)cyclopentanamine 
• 285-67-6 (1S,5R)-6-Oxa-bicyclo[3.1.0]hexane 
• 142-29-0 cyclopentene 
• 285-67-6 Cyclopentene oxide 
• 88807-02-7 (±)-trans-2-azidocyclopentanol 
• 28435-62-3 (+/-)-trans-2-bromocyclopentanol 
• 3350-06-9 2-cyclopentenamine 
• 77644-10-1 (±)-trans-2-phthalimidocyclopentanol 
• 1360145-97-6 (1R,2R)-(-)-2-phthalimidocyclopentan-1-ol 
• 672310-36-0 (R,R)-2-N-benzyloxycarbonylaminocyclopentanol 
• 260065-68-7 (1R,2R)-trans-2-azidocyclopentyl acetate 
• 110716-79-5 (1R,2R)-trans-2-azidocyclopentanol 
• 1360145-98-7 (1S,2S)-(+)-2-phthalimido-1-acetoxy-cyclopentane 

Downstream Products

• 930-45-0 (1S,2S)-2-aminocyclopentanol 
• 930-45-0 (1R,2R)-2-aminocyclopentanol 
• 18721-49-8 2-phenyl-(3ar,6ac)-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole 
• 930-45-0 (+/-)-cis-2-aminocyclopentanol 
• 1236403-63-6 N-[3-({[(1S,2S)-2-hydroxycyclopentyl]amino}methyl)-8-methylquinolin-7-yl]-4-(tetrahydrofuran-2-ylmethoxy)benzamide 
• 77644-10-1 (±)-trans-2-phthalimidocyclopentanol 
• 1360145-97-6 (1R,2R)-(-)-2-phthalimidocyclopentan-1-ol 
• 1360145-98-7 (1S,2S)-(+)-2-phthalimido-1-acetoxy-cyclopentane 
• 1438288-58-4 1-(3-chlorophenethyl)-3-((1S,2S)-2-hydroxycyclopentyl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 99440-98-9 2-hydroxycyclopentanone 
• 1026052-62-9 7-Benzyl-8-biphenyl-4-ylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one 
• 1026223-80-2 7-Benzyl-8-cyclohexylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one 
• 1026282-06-3 7-Benzyl-8-cyclopentylmethyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one 
• 237428-80-7 7,8-Dibenzyl-2-((1R,2R)-2-hydroxy-cyclopentylamino)-1-methyl-1,7-dihydro-purin-6-one 

Relevant articles and documents

Hybrid Organo- and Biocatalytic Process for the Asymmetric Transformation of Alcohols into Amines in Aqueous Medium

A hybrid organo- and biocatalytic system for the asymmetric conversion of racemic alcohols into amines was developed. Combining an organocatalyst, AZADO, an oxidant, NaOCl, and an enzyme, ω-transaminase, we implemented a one-pot oxidation-transamination sequential process in aqueous medium. The method showed broad substrate scope and was successfully applied to conventional secondary alcohols and sterically hindered β-substituted cycloalkanols, where a highly stereoselective dynamic asymmetric bioamination enabled us to set up both contiguous stereocenters with very high enantio- and diastereomeric ratio (>90% yield, >99% ee, and up to 49:1 dr).

FGFR INHIBITORS FOR THE TREATMENT OF CANCER

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A practical method for the synthesis of highly enantioenriched trans -1,2-amino alcohols

A highly enantioselective addition of phenyl carbamate to meso-epoxides has been developed to efficiently generate protected trans-1,2-amino alcohols. This transformation is promoted by an oligomeric (salen)Co-OTf catalyst and has been used to prepare two useful 2-aminocycloalkanol hydrochlorides in enantiopure form on a multigram scale from commercially available starting materials.