cis-(1S,2R)-2-Aminocyclopentanol hydrochloride

Base Information

• Chemical Name: cis-(1S,2R)-2-Aminocyclopentanol hydrochloride
• CAS No.: 225791-13-9
• Molecular Formula: C5H11NO^.HCl
• Molecular Weight: 137.609
• Hs Code.: 2933998090
• Mol file: 225791-13-9.mol

Synonyms:Cyclopentanol,2-amino-, hydrochloride, (1S,2R)- (9CI);Cyclopentanol, 2-amino-, (1S,2R)-, hydrochloride (1:1);(1S,2R)-2-Aminocyclopentanol hydrochloride (1:1);

Chemical Property of cis-(1S,2R)-2-Aminocyclopentanol hydrochloride

Chemical Property:

• Vapor Pressure: 0.0229mmHg at 25°C
• Boiling Point: 220.9 °C at 760 mmHg
• Flash Point: 87.4 °C
• PSA: 46.25000
• LogP: 1.36080
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(1S,2R)-2-Aminocyclopentanolhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (1S,2R)-2-Aminocyclopentanol, HCl

Technology Process of cis-(1S,2R)-2-Aminocyclopentanol hydrochloride

There total 5 articles about cis-(1S,2R)-2-Aminocyclopentanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(dimethylamino)ethyl chloride (107-99-3) + diethyl 2-benzylmalonate (607-81-8) → 2-benzyl-2-[2-(dimethylamino)ethyl]malonic acid diethyl ester (1805-03-4)

Guidance literature:

diethyl 2-benzylmalonate; With sodium hydride; In toluene; for 1h; Heating;

2-(dimethylamino)ethyl chloride; In toluene; for 6h; Further stages.; Heating;

DOI:10.1021/jm020895l

Reference yield:

(S,R)-4,5,6,6a-tetrahydro-2-methyl-3aH-cyclopentoxazole hydrochloride → (1S,2R)-2-aminocyclopentanol hydrochloride salt (225791-13-9)

Guidance literature:

With hydrogenchloride; In methanol; ethanol;

Reference yield:

diethyl 2-benzylmalonate (607-81-8) → 2-benzyl-2-[2-(dimethylamino)ethyl]malonic acid diethyl ester (1805-03-4)

Guidance literature:

With sodium; xylene; anschliessendes Erhitzen mit Dimethyl-<2-chlor-aethyl>-amin;

DOI:10.1039/jr9350000722

upstream raw materials:

diethyl 2-benzylmalonate

2-(dimethylamino)ethyl chloride

Downstream raw materials:

tert-butyl N-[(1S,2R)-2-hydroxycyclopentyl]carbamate

Refernces

• 1、 -. "N-(2-HYDROXYCYCLOPENTYL)-1-ISOPROPYL-6-METHYLERGOLINE-8-CARBOXAMIDES". . . Retrieved 2008/06/13.