2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-1-[1S-amino-3-methbutyl]-5-trifluoromethylbenzene

Base Information

Chemical Name:2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-1-[1S-amino-3-methbutyl]-5-trifluoromethylbenzene
CAS No.:626212-09-7
Molecular Formula:C₂₅H₃₀Cl₂F₃N₃O
Molecular Weight:516.434
Hs Code.:

Synonyms:2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-1-[1S-amino-3-methbutyl]-5-trifluoromethylbenzene

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Chemical Property of 2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-1-[1S-amino-3-methbutyl]-5-trifluoromethylbenzene

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Technology Process of 2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-1-[1S-amino-3-methbutyl]-5-trifluoromethylbenzene

There total 6 articles about 2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-1-[1S-amino-3-methbutyl]-5-trifluoromethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-Methyl-propane-2-sulfinic acid [(S)-1-(2-{4-[3-(2,4-dichloro-phenyl)-propionyl]-piperazin-1-yl}-5-trifluoromethyl-phenyl)-3-methyl-butyl]-amide

: 626212-09-7
2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-1-[1S-amino-3-methbutyl]-5-trifluoromethylbenzene

Guidance literature:: With hydrogenchloride; In methanol;
DOI:10.1016/j.bmcl.2006.05.088

Reference yield:

: 626219-95-2
4-(2-formyl-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 626212-09-7
2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-1-[1S-amino-3-methbutyl]-5-trifluoromethylbenzene

Guidance literature:: Multi-step reaction with 5 steps

1: Ti(OEt)4 / tetrahydrofuran / 20 °C

2: Me₃Al / tetrahydrofuran / -78 °C

3: trifluoroacetic acid / CH₂Cl₂

4: EDC / dimethylformamide; CH₂Cl₂

5: HCl / methanol

With hydrogenchloride; titanium(IV) tetraethanolate; trimethylaluminum; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.088

Reference yield:

: 869478-23-9
4-{2-[((S_S)-2-methyl-propane-2-sulfinylimino)-methyl]-4-trifluoromethyl-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

: 626212-09-7
2-{4-[3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-1-[1S-amino-3-methbutyl]-5-trifluoromethylbenzene

Guidance literature:: Multi-step reaction with 4 steps

1: Me₃Al / tetrahydrofuran / -78 °C

2: trifluoroacetic acid / CH₂Cl₂

3: EDC / dimethylformamide; CH₂Cl₂

4: HCl / methanol

With hydrogenchloride; trimethylaluminum; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.05.088