2-Amino-2,3-dimethylbutyramide

Base Information

• Chemical Name: 2-Amino-2,3-dimethylbutyramide
• CAS No.: 40963-14-2
• Molecular Formula: C6H14N2O
• Molecular Weight: 130.19
• Hs Code.: 2921199090
• European Community (EC) Number: 817-314-6
• Nikkaji Number: J3.001.609B
• Mol file: 40963-14-2.mol

Synonyms:2-Amino-2,3-dimethylbutyramide;40963-14-2;2-amino-2,3-dimethylbutanamide;2-Amino-2,3-dimethyl butyramide;Butanamide, 2-amino-2,3-dimethyl-;MFCD02682920;2-amino-2,3-dimethyl-butanamide;2-amino-2,3dimethylbutyramide;SCHEMBL7554026;YCPQUHCGFDFLSI-UHFFFAOYSA-N;2-amino-2,3-dimethyl- butyramide;BCP14288;(+)-2-amino-2,3-dimethylbutyramide;(+/-)-2-amino2,3dimethylbutyramide;(-)-2-amino-2,3-dimethylbutyramide;AKOS008901283;AC-1896;GS-3291;2-amino-2,3-dimethylbutyric acid amide;(+/-)-2-amino-2,3-dimethylbutyramide;2-amino-2,3-dimethyl-butyric acid amide;CS-0019531;FT-0648930;FT-0660062;EN300-206255;O10642;A825366

Chemical Property of 2-Amino-2,3-dimethylbutyramide

Chemical Property:

• Vapor Pressure: 0.034mmHg at 25°C
• Refractive Index: 1.469
• Boiling Point: 242.664 °C at 760 mmHg
• PKA: 16.12±0.50(Predicted)
• Flash Point: 100.56 °C
• PSA: 69.11000
• Density: 0.983 g/cm³
• LogP: 1.24570
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 130.110613074
• Heavy Atom Count: 9
• Complexity: 122

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-2,3-dimethylbutyramide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)C(C)(C(=O)N)N
• Uses: 2-Amino-2,3-dimethylbutyramide is an important intermediate in the synthesis of potent imadazoline herbicides. In addition, it is used to prepare new chiral ligands.

Technology Process of 2-Amino-2,3-dimethylbutyramide

There total 3 articles about 2-Amino-2,3-dimethylbutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.3%

2-amino-2,3-dimethylbutyronitrile (13893-53-3) → 2-amino-2,3-dimethylbutyramide (40963-14-2)

Guidance literature:

With water; In aq. phosphate buffer; at 20 ℃; pH=7; Concentration; pH-value; Temperature; Solvent; Microbiological reaction; Green chemistry; Enzymatic reaction;

DOI:10.1039/c5gc00169b

Reference yield:

ammonium hydroxide (1336-21-6) + 2-amino-2,3-dimethylbutyronitrile (13893-53-3) → 2-amino-2,3-dimethylbutyramide (40963-14-2)

Guidance literature:

With sulfuric acid; In ice-acetone;

Reference yield:

→ 2-amino-2,3-dimethylbutyramide (40963-14-2)

Guidance literature:

upstream raw materials:

2-amino-2,3-dimethylbutyronitrile

ammonium hydroxide

Downstream raw materials:

2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid

(S)-α-Methylvaline

(+)-(R)-2-amino-2,3-dimethylbutanamide

imazapic

Refernces

• 1、 Mitas, Petr,Sedlak, Milos,Kavalek, Jaromir. "Substituent effect on acidity of substituted 2-(4-nitrobenzoylamino)alkanamidesin methanol-dimethyl sulfoxide mixtures". . p. 85 - 93. Retrieved 2007/10/03.
• 2、 -. "Regio and optical isomers of imidazolinyl toluic acids, esters and salts, their method of preparation and their use as herbicidal agents". . . Retrieved 2008/06/13.