2-[4-hydroxy-3'-(N-hydroxyamidino)biphenyl-3-yl]-1H-benzimidazole-5-N-hydroxyamidine

Base Information

Chemical Name:2-[4-hydroxy-3'-(N-hydroxyamidino)biphenyl-3-yl]-1H-benzimidazole-5-N-hydroxyamidine
CAS No.:769972-12-5
Molecular Formula:C₂₁H₁₈N₆O₃
Molecular Weight:402.412
Hs Code.:

Synonyms:2-[4-hydroxy-3'-(N-hydroxyamidino)biphenyl-3-yl]-1H-benzimidazole-5-N-hydroxyamidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[4-hydroxy-3'-(N-hydroxyamidino)biphenyl-3-yl]-1H-benzimidazole-5-N-hydroxyamidine

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Technology Process of 2-[4-hydroxy-3'-(N-hydroxyamidino)biphenyl-3-yl]-1H-benzimidazole-5-N-hydroxyamidine

There total 4 articles about 2-[4-hydroxy-3'-(N-hydroxyamidino)biphenyl-3-yl]-1H-benzimidazole-5-N-hydroxyamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 769972-03-4
2-(3'-cyano-4-hydroxybiphenyl-3-yl)-1H-benzimidazole-5-carbonitrile

: 769972-12-5
2-[4-hydroxy-3'-(N-hydroxyamidino)biphenyl-3-yl]-1H-benzimidazole-5-N-hydroxyamidine

Guidance literature:: With hydroxylamine hydrochloride; potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1016/j.bmc.2004.07.056

Reference yield:

: 1761-61-1
5-bromosalicyclaldehyde

: 769972-12-5
2-[4-hydroxy-3'-(N-hydroxyamidino)biphenyl-3-yl]-1H-benzimidazole-5-N-hydroxyamidine

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / toluene; methanol / 12 h / 80 °C

2: 89 percent / 1,4-benzoquinone / ethanol / Heating

3: 97 percent / NH₂OH*HCl; t-BuOK / dimethylsulfoxide / 20 °C

With hydroxylamine hydrochloride; potassium tert-butylate; sodium carbonate; p-benzoquinone; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; dimethyl sulfoxide; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2004.07.056

Reference yield:

: 17626-40-3
4-cyano-1,2-phenylenediamine

: 769972-12-5
2-[4-hydroxy-3'-(N-hydroxyamidino)biphenyl-3-yl]-1H-benzimidazole-5-N-hydroxyamidine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 1,4-benzoquinone / ethanol / Heating

2: 97 percent / NH₂OH*HCl; t-BuOK / dimethylsulfoxide / 20 °C

With hydroxylamine hydrochloride; potassium tert-butylate; p-benzoquinone; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2004.07.056