1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid sodium salt

Base Information

• Chemical Name: 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid sodium salt
• CAS No.: 1203588-10-6
• Molecular Formula: C₂₂H₂₁F₃NO₄S*Na
• Molecular Weight: 475.464
• Mol file: 1203588-10-6.mol

Synonyms:1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid sodium salt

Chemical Property of 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid sodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid sodium salt

There total 5 articles about 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-[[3-(1-Methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid (1203588-09-3) → 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid sodium salt (1203588-10-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 6h;

Reference yield:

m-cumenesulfonyl chloride (71530-58-0) → 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid sodium salt (1203588-10-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / 15 h / 20 °C

2.1: copper(II) acetate monohydrate / 1,2-dichloro-ethane / 15 h / Inert atmosphere; Reflux

3.1: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

3.2: 0 °C

4.1: sodium hydroxide / water; tetrahydrofuran / 6 h / 20 °C

With pyridine; water; copper(II) acetate monohydrate; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane;

Reference yield:

6-[2-(((3-(1-Methylethyl)phenyl)sulphonyl)amino]-5-(trifluoro-methyl)phenyl]-5-hexynoic acid, methyl ester (1203588-07-1) → 1-[[3-(1-methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid sodium salt (1203588-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper(II) acetate monohydrate / 1,2-dichloro-ethane / 15 h / Inert atmosphere; Reflux

2.1: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

2.2: 0 °C

3.1: sodium hydroxide / water; tetrahydrofuran / 6 h / 20 °C

With water; copper(II) acetate monohydrate; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane;

upstream raw materials:

methyl 6-[2-amino-5-(trifluoromethyl)phenyl]hex-5-ynoate

m-cumenesulfonyl chloride

6-[2-(((3-(1-Methylethyl)phenyl)sulphonyl)amino]-5-(trifluoro-methyl)phenyl]-5-hexynoic acid, methyl ester

1-[[3-(1-Methylethyl)phenyl]sulphonyl]-5-(trifluoromethyl)-1H-indole-2-butanoic acid

Refernces