2-Amino-4-methyl-5-bromopyrimidine

Base Information

• Chemical Name: 2-Amino-4-methyl-5-bromopyrimidine
• CAS No.: 17321-93-6
• Molecular Formula: C5H6BrN3
• Molecular Weight: 188.027
• Hs Code.: 29335990
• Mol file: 17321-93-6.mol

Synonyms:Pyrimidine,2-amino-5-bromo-4-methyl- (7CI,8CI);(5-Bromo-4-methylpyrimidin-2-yl)amine;5-Bromo-4-methyl-2-pyrimidinamine;

Chemical Property of 2-Amino-4-methyl-5-bromopyrimidine

Chemical Property:

• Vapor Pressure: 6.18E-05mmHg at 25°C
• Melting Point: 192-194℃
• Refractive Index: 1.626
• Boiling Point: 345.4 °C at 760 mmHg
• PKA: 2.47±0.10(Predicted)
• Flash Point: 162.7 °C
• PSA: 51.80000
• Density: 1.699 g/cm³
• LogP: 1.71090
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-bromo-4-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-4-methyl-5-bromopyrimidine

There total 2 articles about 2-Amino-4-methyl-5-bromopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Methyl-pyrimidin-2-ylamin (108-52-1) → 5-bromo-4-methylpyrimidine-2-ylamine (17321-93-6)

Guidance literature:

4-Methyl-pyrimidin-2-ylamin; With N-Bromosuccinimide; In chloroform; for 15h;

With sodium hydroxide; In dichloromethane; chloroform; water;

Reference yield:

→ 5-bromo-4-methylpyrimidine-2-ylamine (17321-93-6)

Guidance literature:

2-Amino-4-methylpyrimidin, NBS/sd.CCl4;

Reference yield: 79.0%

5-bromo-4-methylpyrimidine-2-ylamine (17321-93-6) + p-methoxybenzyl chloride (824-94-2) → 5-bromo-N,N-bis(4-methoxybenzyl)-4-methylpyrimidin-2-amine

Guidance literature:

5-bromo-4-methylpyrimidine-2-ylamine; With sodium hydride; In mineral oil; at 0 ℃; for 0.5h;

p-methoxybenzyl chloride; With sodium iodide; In mineral oil; at 0 - 20 ℃; for 5h;

DOI:10.1016/j.bmc.2016.04.060

upstream raw materials:

4-Methyl-pyrimidin-2-ylamin

Downstream raw materials:

4-acetylamino-N-(5-bromo-4-methyl-pyrimidin-2-yl)-benzenesulfonamide

2-amino-4-methylpyrimidine-5-carbonitrile

5-aminomethyl-4-methyl-pyrimidin-2-ylamine

sulfanilic acid-(5-bromo-4-methyl-pyrimidin-2-ylamide)

Refernces

• 1、 Heffron, Timothy P.,Ndubaku, Chudi O.,Salphati, Laurent,Alicke, Bruno,Cheong, Jonathan,Drobnick, Joy,Edgar, Kyle,Gould, Stephen E.,Lee, Leslie B.,Lesnick, John D.,Lewis, Cristina,Nonomiya, Jim,Pang, Jodie,Plise, Emile G.,Sideris, Steve,Wallin, Jeffrey,Wang, Lan,Zhang, Xiaolin,Olivero, Alan G.. "Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR". supporting information. p. 351 - 356. Retrieved 2016/05/19.
• 2、 -. "DIOXINO-AND OXAZIN-[2,3-D]PYRIMIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE". Paragraph 0197; 0198. . Retrieved 2014/03/25.