4-{2-[2-(Naphthalene-1-sulfonylamino)-acetylamino]-3-oxo-3-piperidin-1-yl-propyl}-thiobenzimidic acid methyl ester; hydriodide

Base Information

Chemical Name:4-{2-[2-(Naphthalene-1-sulfonylamino)-acetylamino]-3-oxo-3-piperidin-1-yl-propyl}-thiobenzimidic acid methyl ester; hydriodide
CAS No.:92740-68-6
Molecular Formula:C₂₈H₃₂N₄O₄S₂*HI
Molecular Weight:680.631
Hs Code.:

Synonyms:4-{2-[2-(Naphthalene-1-sulfonylamino)-acetylamino]-3-oxo-3-piperidin-1-yl-propyl}-thiobenzimidic acid methyl ester; hydriodide

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Chemical Property of 4-{2-[2-(Naphthalene-1-sulfonylamino)-acetylamino]-3-oxo-3-piperidin-1-yl-propyl}-thiobenzimidic acid methyl ester; hydriodide

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Technology Process of 4-{2-[2-(Naphthalene-1-sulfonylamino)-acetylamino]-3-oxo-3-piperidin-1-yl-propyl}-thiobenzimidic acid methyl ester; hydriodide

There total 9 articles about 4-{2-[2-(Naphthalene-1-sulfonylamino)-acetylamino]-3-oxo-3-piperidin-1-yl-propyl}-thiobenzimidic acid methyl ester; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 92740-56-2
2-(Naphthalene-1-sulfonylamino)-N-[2-oxo-2-piperidin-1-yl-1-(4-thiocarbamoyl-benzyl)-ethyl]-acetamide

: 74-88-4
methyl iodide

: 92740-68-6
4-{2-[2-(Naphthalene-1-sulfonylamino)-acetylamino]-3-oxo-3-piperidin-1-yl-propyl}-thiobenzimidic acid methyl ester; hydriodide

Guidance literature:: In acetone; for 0.166667h; Heating;

Reference yield:

: 110-89-4
piperidine

: 92740-68-6
4-{2-[2-(Naphthalene-1-sulfonylamino)-acetylamino]-3-oxo-3-piperidin-1-yl-propyl}-thiobenzimidic acid methyl ester; hydriodide

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / pyridine; dimethylformamide / 7 h / Ambient temperature

2: 80 percent / H₂S, TEA / pyridine / 72 h / Ambient temperature

3: 65 percent / acetone / 0.17 h / Heating

With TEA; hydrogen sulfide; In pyridine; N,N-dimethyl-formamide; acetone;

Reference yield:

: 52117-01-8
N-acetyl-4-cyano-α-(ethoxycarbonyl)phenylalanine ethyl ester

: 92740-68-6
4-{2-[2-(Naphthalene-1-sulfonylamino)-acetylamino]-3-oxo-3-piperidin-1-yl-propyl}-thiobenzimidic acid methyl ester; hydriodide

Guidance literature:: Multi-step reaction with 6 steps

1: NaOH (1 mol/l) / acetic acid; H₂O / pH 3.8-4.0

2: NaOH (1 mol/l) / diethyl ether; ethyl acetate; H₂O / 10 h

3: DCC / pyridine / 12 h / Ambient temperature

4: 40 percent / pyridine; dimethylformamide / 7 h / Ambient temperature

5: 80 percent / H₂S, TEA / pyridine / 72 h / Ambient temperature

6: 65 percent / acetone / 0.17 h / Heating

With sodium hydroxide; TEA; hydrogen sulfide; dicyclohexyl-carbodiimide; In pyridine; diethyl ether; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone;