acetic acid (2E,6E,10E)-12-(4-formyloxy-2-methoxy-phenoxy)-3,7,11-trimethyl-dodeca-2,6,10-trienyl ester

Base Information

• Chemical Name: acetic acid (2E,6E,10E)-12-(4-formyloxy-2-methoxy-phenoxy)-3,7,11-trimethyl-dodeca-2,6,10-trienyl ester
• CAS No.: 851341-17-8
• Molecular Formula: C₂₅H₃₄O₆
• Molecular Weight: 430.541
• Mol file: 851341-17-8.mol

Synonyms:acetic acid (2E,6E,10E)-12-(4-formyloxy-2-methoxy-phenoxy)-3,7,11-trimethyl-dodeca-2,6,10-trienyl ester

Chemical Property of acetic acid (2E,6E,10E)-12-(4-formyloxy-2-methoxy-phenoxy)-3,7,11-trimethyl-dodeca-2,6,10-trienyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acetic acid (2E,6E,10E)-12-(4-formyloxy-2-methoxy-phenoxy)-3,7,11-trimethyl-dodeca-2,6,10-trienyl ester

There total 1 articles about acetic acid (2E,6E,10E)-12-(4-formyloxy-2-methoxy-phenoxy)-3,7,11-trimethyl-dodeca-2,6,10-trienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E,6E)-farnesyl acetate (4128-17-0) → acetic acid (2E,6E,10E)-12-(4-formyloxy-2-methoxy-phenoxy)-3,7,11-trimethyl-dodeca-2,6,10-trienyl ester (851341-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SeO₂; salicylic acid; TBHP / CH₂Cl₂

2: 75 percent / DEAD; Ph₃P / tetrahydrofuran

With tert.-butylhydroperoxide; selenium(IV) oxide; triphenylphosphine; salicylic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;

DOI:10.1055/s-2005-863713

Reference yield: 94.0%

acetic acid (2E,6E,10E)-12-(4-formyloxy-2-methoxy-phenoxy)-3,7,11-trimethyl-dodeca-2,6,10-trienyl ester (851341-17-8) → 4-[(2E,6E,10E)-12-hydroxy-2,6,10-trimethyl-dodeca-2,6,10-trienyloxy]-3-methoxy-phenol (945609-15-4)

Guidance literature:

With methanol; potassium carbonate; for 2h;

DOI:10.1016/j.tet.2007.03.069

Reference yield:

acetic acid (2E,6E,10E)-12-(4-formyloxy-2-methoxy-phenoxy)-3,7,11-trimethyl-dodeca-2,6,10-trienyl ester (851341-17-8) → (6E,10E)-11-((4-hydroxy-2-methoxyphenoxy)methyl)-3,7-dimethyldodeca-2,6,10-trienal

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / potassium carbonate; methanol / 2 h

2: 87 percent / dimethyl sulfoxide; SO₃ pyridine complex; triethylamine / tetrahydrofuran / 3 h

With methanol; sulfur trioxide pyridine complex; potassium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran;

DOI:10.1016/j.tet.2007.03.069

upstream raw materials:

(2E,6E)-farnesyl acetate

Downstream raw materials:

4-[(2E,6E,10E)-12-hydroxy-2,6,10-trimethyl-dodeca-2,6,10-trienyloxy]-3-methoxy-phenol