N-[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]-furan-5-yl]glycinamide hydrochloride

Base Information

Chemical Name:N-[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]-furan-5-yl]glycinamide hydrochloride
CAS No.:1338924-75-6
Molecular Formula:C₂₂H₂₄N₂O₇*ClH
Molecular Weight:464.903
Hs Code.:

Synonyms:N-[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]-furan-5-yl]glycinamide hydrochloride

Suppliers and Price of N-[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]-furan-5-yl]glycinamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]-furan-5-yl]glycinamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]-furan-5-yl]glycinamide hydrochloride

There total 4 articles about N-[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]-furan-5-yl]glycinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1338924-73-4
tert-butyl-(2-{[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]furan-5-yl]amino}-2-oxoethyl)carbamate

: 1338924-75-6
N-[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]-furan-5-yl]glycinamide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/cmdc.201100279

Reference yield:

: 1338924-36-9
C₂₀H₁₉NO₈

: 1338924-75-6
N-[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]-furan-5-yl]glycinamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; iron / ethanol; water; acetic acid / 0.67 h / Reflux; Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere; Cooling with ice

3: hydrogenchloride / methanol / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; iron; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100279

Reference yield:

: 51490-01-8
1-(3,4,5-trimethoxyphenyl)-2-bromoethanone

: 1338924-75-6
N-[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]-furan-5-yl]glycinamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 18 h / Reflux; Inert atmosphere

2: hydrogenchloride; iron / ethanol; water; acetic acid / 0.67 h / Reflux; Inert atmosphere

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere; Cooling with ice

4: hydrogenchloride / methanol / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; iron; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1002/cmdc.201100279