tert-butyl-(2-{[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]furan-5-yl]amino}-2-oxoethyl)carbamate

Base Information

Chemical Name:tert-butyl-(2-{[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]furan-5-yl]amino}-2-oxoethyl)carbamate
CAS No.:1338924-73-4
Molecular Formula:C₂₇H₃₂N₂O₉
Molecular Weight:528.559
Hs Code.:

Synonyms:tert-butyl-(2-{[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]furan-5-yl]amino}-2-oxoethyl)carbamate

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Chemical Property of tert-butyl-(2-{[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]furan-5-yl]amino}-2-oxoethyl)carbamate

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Technology Process of tert-butyl-(2-{[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]furan-5-yl]amino}-2-oxoethyl)carbamate

There total 4 articles about tert-butyl-(2-{[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]furan-5-yl]amino}-2-oxoethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 4530-20-5
BOC-glycine

: 1338924-50-7
(5-amino-3-methyl-6-methoxybenzo[b]furan-2-yl)(3,4,5-trimethoxyphenyl)methanone

: 1338924-73-4
tert-butyl-(2-{[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]furan-5-yl]amino}-2-oxoethyl)carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere; Cooling with ice;
DOI:10.1002/cmdc.201100279

Reference yield:

: 1338924-36-9
C₂₀H₁₉NO₈

: 1338924-73-4
tert-butyl-(2-{[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]furan-5-yl]amino}-2-oxoethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; iron / ethanol; water; acetic acid / 0.67 h / Reflux; Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere; Cooling with ice

With hydrogenchloride; iron; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201100279

Reference yield:

: 51490-01-8
1-(3,4,5-trimethoxyphenyl)-2-bromoethanone

: 1338924-73-4
tert-butyl-(2-{[6-methoxy-3-methyl-2-(3,4,5-trimethoxybenzoyl)-1-benzo[b]furan-5-yl]amino}-2-oxoethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 18 h / Reflux; Inert atmosphere

2: hydrogenchloride; iron / ethanol; water; acetic acid / 0.67 h / Reflux; Inert atmosphere

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere; Cooling with ice

With hydrogenchloride; iron; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1002/cmdc.201100279