(S)-(+)-2-cyano-2-methylphenylacetic acid

Base Information

Chemical Name:(S)-(+)-2-cyano-2-methylphenylacetic acid
CAS No.:29738-04-3
Molecular Formula:C₁₀H₉NO₂
Molecular Weight:175.187
Hs Code.:

Synonyms:(S)-(+)-2-cyano-2-methylphenylacetic acid

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Chemical Property of (S)-(+)-2-cyano-2-methylphenylacetic acid

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Technology Process of (S)-(+)-2-cyano-2-methylphenylacetic acid

There total 14 articles about (S)-(+)-2-cyano-2-methylphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1823-91-2
1-phenylethyl cyanide

: 1200-71-1,29738-03-2,35677-21-5,29738-04-3
2-cyano-2-phenylpropionic acid

Guidance literature:: 1-phenylethyl cyanide; With lithium hexamethyldisilazane; In tetrahydrofuran;

carbon dioxide; In tetrahydrofuran;

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1039/c1pp05080j

Reference yield: 73.0%

: 526221-30-7
(S)-3-Hydroxy-2-methyl-2-phenyl-propionitrile

: 29738-04-3
(S)-(+)-2-cyano-2-methylphenylacetic acid

Guidance literature:: With jones' reagent; In acetone; at 0 ℃; for 0.166667h;
DOI:10.1246/cl.2003.4

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 29738-04-3
(S)-(+)-2-cyano-2-methylphenylacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / tetrahydrofuran / 2 h / 20 °C

2: 50 percent aq. NaOH; cetyltrimethylammonium chloride / 18 h / 80 °C

3: aq. conc. HCl / methanol / 2 h / 20 °C

4: K₂CO₃ / methanol / 0.17 h / 20 °C

5: 71 percent / 18-crown-6 / tetrahydrofuran / 12 h / 20 °C

6: 90 percent / NaBH₄ / methanol / 0.17 h / 20 °C

7: 73 percent / Jones' reagent / acetone / 0.17 h / 0 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; jones' reagent; cetyltrimethylammonium chloride; potassium carbonate; triethylamine; 18-crown-6 ether; In tetrahydrofuran; methanol; acetone;
DOI:10.1246/cl.2003.4