2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

Base Information

Chemical Name:2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate
CAS No.:1415829-75-2
Molecular Formula:C₃₄H₃₁N₇O₈S
Molecular Weight:697.728
Hs Code.:

Synonyms:2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

Suppliers and Price of 2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

There total 9 articles about 2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 7423-55-4
3-maleimidepropionic acid

: C₂₇H₂₆N₆O₅S*C₂HF₃O₂

: 1415829-75-2
2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1002/psc.3353

Reference yield: 56.5%

: 7423-55-4
3-maleimidepropionic acid

: 1415830-70-4
2-(2-aminoethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

: 1415829-75-2
2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

Guidance literature:: 3-maleimidepropionic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Inert atmosphere;

2-(2-aminoethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 4-sulfamoylbenzoyl azide

: 1415829-75-2
2-(2-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethoxy)ethyl 4-(N-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yl)sulfamoyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 16 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C

2.2: 16 h / 100 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Cooling with ice

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C

With sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;