1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-4-hydroxypiperidin-1-yl)propan-1-one hydrochloride

Base Information

• Chemical Name: 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-4-hydroxypiperidin-1-yl)propan-1-one hydrochloride
• CAS No.: 1394147-91-1
• Molecular Formula: C₂₃H₂₅NO₂S*ClH
• Molecular Weight: 415.984

Synonyms:1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-4-hydroxypiperidin-1-yl)propan-1-one hydrochloride

Chemical Property of 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-4-hydroxypiperidin-1-yl)propan-1-one hydrochloride

Chemical Property:

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Technology Process of 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-4-hydroxypiperidin-1-yl)propan-1-one hydrochloride

There total 1 articles about 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-4-hydroxypiperidin-1-yl)propan-1-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.3%

4-benzylpiperidin-4-ol hydrochloride + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-acetylbenzothiophene (1128-05-8) → 1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-4-hydroxypiperidin-1-yl)propan-1-one hydrochloride (1394147-91-1)

Guidance literature:

4-benzylpiperidin-4-ol hydrochloride; formaldehyd; 3-acetylbenzothiophene; With hydrogenchloride; In ethanol; water; for 5h; Reflux;

With hydrogenchloride; In ethanol; ethyl acetate; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2012.04.030

Reference yield:

1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-4-hydroxypiperidin-1-yl)propan-1-one hydrochloride (1394147-91-1) → 1-(3-(benzo[b]thiophen-3-yl)-3-hydroxypropyl)-4-benzylpiperidin-4-ol (1394204-52-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2012.04.030

Reference yield:

1-(benzo[b]thiophen-3-yl)-3-(4-benzyl-4-hydroxypiperidin-1-yl)propan-1-one hydrochloride (1394147-91-1) → 1-(3-(benzo[b]thiophen-3-yl)-3-hydroxypropyl)-4-benzylpiperidin-4-ol hydrochloride (1394147-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 2 h / 20 °C

2: hydrogenchloride / ethanol; ethyl acetate / 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; In methanol; ethanol; ethyl acetate;

DOI:10.1016/j.ejmech.2012.04.030

upstream raw materials:

formaldehyd

3-acetylbenzothiophene

Downstream raw materials:

1-(3-(benzo[b]thiophen-3-yl)-3-hydroxypropyl)-4-benzylpiperidin-4-ol

1-(3-(benzo[b]thiophen-3-yl)-3-hydroxypropyl)-4-benzylpiperidin-4-ol hydrochloride

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