N-(5-(((1R,4R)-4-aminocyclohexyl)methyl)-4-(ethylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-methoxybenzamide

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Chemical Name:N-(5-(((1R,4R)-4-aminocyclohexyl)methyl)-4-(ethylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-methoxybenzamide
CAS No.:1415565-54-6
Molecular Formula:C₂₃H₃₀N₆O₂
Molecular Weight:422.53
Hs Code.:

Synonyms:N-(5-(((1R,4R)-4-aminocyclohexyl)methyl)-4-(ethylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-methoxybenzamide

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Chemical Property of N-(5-(((1R,4R)-4-aminocyclohexyl)methyl)-4-(ethylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-methoxybenzamide

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Technology Process of N-(5-(((1R,4R)-4-aminocyclohexyl)methyl)-4-(ethylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-methoxybenzamide

There total 6 articles about N-(5-(((1R,4R)-4-aminocyclohexyl)methyl)-4-(ethylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1415565-53-5
C₂₈H₃₈N₆O₄

: 1415565-54-6
N-(5-(((1R,4R)-4-aminocyclohexyl)methyl)-4-(ethylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-methoxybenzamide

Guidance literature:: C₂₈H₃₈N₆O₄; With trifluoroacetic acid; In dichloromethane; at 60 ℃; for 4h;

With sodium hydrogencarbonate; In dichloromethane; water;
DOI:10.1021/co300106f

Reference yield:

: 1415565-25-1
N-benzyl-N-ethyl-7-nitro-5H-pyrrolo[3,2-d]pyrimidin-4-amine

: 1415565-54-6
N-(5-(((1R,4R)-4-aminocyclohexyl)methyl)-4-(ethylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-methoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 150 °C / Microwave irradiation

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3: triethylamine; dmap / tetrahydrofuran / 5 h / 20 °C

4: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 6 h / 60 °C

5: trifluoroacetic acid / dichloromethane / 4 h / 60 °C

With dmap; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/co300106f

Reference yield:

: 1260676-83-2
4-chloro-7-nitro-5H-pyrrolo[3,2-d]pyrimidine

: 1415565-54-6
N-(5-(((1R,4R)-4-aminocyclohexyl)methyl)-4-(ethylamino)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-methoxybenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: isopropyl alcohol / 80 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 150 °C / Microwave irradiation

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

4: triethylamine; dmap / tetrahydrofuran / 5 h / 20 °C

5: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 6 h / 60 °C

6: trifluoroacetic acid / dichloromethane / 4 h / 60 °C

With dmap; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/co300106f