benzo[b]thiophen-2-yl-(3,4,5-trimethoxy-phenyl)-methanone

Base Information

• Chemical Name: benzo[b]thiophen-2-yl-(3,4,5-trimethoxy-phenyl)-methanone
• CAS No.: 1151995-55-9
• Molecular Formula: C₁₈H₁₆O₄S
• Molecular Weight: 328.389
• Mol file: 1151995-55-9.mol

Synonyms:benzo[b]thiophen-2-yl-(3,4,5-trimethoxy-phenyl)-methanone

Chemical Property of benzo[b]thiophen-2-yl-(3,4,5-trimethoxy-phenyl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzo[b]thiophen-2-yl-(3,4,5-trimethoxy-phenyl)-methanone

There total 6 articles about benzo[b]thiophen-2-yl-(3,4,5-trimethoxy-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

α-(2-benzo[b]thienyl)-3,4,5-trimethoxybenzyl alcohol → benzo[b]thiophen-2-yl-(3,4,5-trimethoxy-phenyl)-methanone (1151995-55-9)

Guidance literature:

With manganese(IV) oxide; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmcl.2015.11.010

Reference yield: 96.0%

1-(3,4,5-trimethoxyphenyl)-2-bromoethanone (51490-01-8) + 2-formylthiophenol (29199-11-9) → benzo[b]thiophen-2-yl-(3,4,5-trimethoxy-phenyl)-methanone (1151995-55-9)

Guidance literature:

With potassium carbonate; In acetone; for 18h; Reflux;

DOI:10.1016/j.bmc.2010.05.068

Reference yield: 92.0%

C18H19IO4 → benzo[b]thiophen-2-yl-(3,4,5-trimethoxy-phenyl)-methanone (1151995-55-9)

Guidance literature:

C₁₈H₁₉IO₄; With copper(l) iodide; potassium ethyl xanthogenate; In N,N-dimethyl-formamide; at 100 ℃; for 24h;

With sulfuric acid; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1039/d0cc04647g

upstream raw materials:

1-(3,4,5-trimethoxyphenyl)-2-bromoethanone

2-formylthiophenol

Benzo[b]thiophene

3,4,5-trimethoxy-benzaldehyde