29199-11-9Relevant academic research and scientific papers
Synthesis, characterization and supramolecular building motifs of substituted salphen- and thiasalphen–metal complexes
Kumar, Nitesh,Asatkar, Ashish K.,Panda, Snigdha,Zade, Sanjio S.
, p. 718 - 728 (2016)
Two new series of substituted salphen-metal complexes and thiasalphen–metal complexes have been synthesized. The fluorine substituted salphen-metal complexes (5, 6 and 7) were prepared by the coordination of ligand 4 (obtained by the reaction of 4,5-difluorosalicylaldehyde with o-phenylenediamine) with Ni(II), Cu(II) and Zn(II) ions, respectively. The thiasalphen–metal complexes (8, 9 and 10) were prepared strategically following the unique route of the in situ reduction of bis(o-formylphenyl)disulfide to mercaptobenzaldehyde then complexation with Ni(II), Cu(II) and Zn(II) ions, followed by Schiff base coupling with o-phenylenediamine, in a single pot. The products were characterized by elemental analysis, ESI-MS, FT-IR and1H/13C NMR spectroscopy. The structures of 4, 5, 6, 9 and 10 were established by single crystal X-ray analysis. The various non-bonding interactions resulted in fascinating supramolecular building motifs. The photophysical and electrochemical properties (band gaps, HOMO?LUMO energies) of all the six complexes were studied by UV–Vis spectroscopy and cyclic voltammetry. The optical band gaps were found to be in the range 2.31–2.79?eV.
Aldimine-Thioether-Phenolate Based Mono- and Bimetallic Zinc Complexes as Catalysts for the Reaction of CO2 with Cyclohexene Oxide
Cozzolino, Mariachiara,Melchionno, Flavia,Santulli, Federica,Mazzeo, Mina,Lamberti, Marina
, p. 1645 - 1653 (2020)
A synthetic strategy for the preparation of a new class of ligands is introduced. The bis(aldimine-thioether-phenolate) ligands bear two anionic oxygen donors from phenolate moieties, two neutral sulfur donors and two neutral nitrogen donors belonging, respectively, to thioether and aldimine functionalities. The so designed OSNNSO ligands show two coordinative pockets and thus should be able to host two metallic centers. Instead, the aldimine-thioether-phenolate OSN ligands are tridentate ligands which may form monometallic complexes. Two OSNNSO and one OSN ligands of this class, have been synthesized. Satisfyingly, by direct reaction of the ligands with one or two equivalents of the zinc precursor, the corresponding bimetallic Zn(II) complexes were prepared from the bis(aldimine-thioether-phenolate) ligands, while the monometallic zinc complex was prepared from the tridentate ligand. These zinc amido complexes act as single component catalysts in the reaction of CO2 with cyclohexene oxide by furnishing polycyclohexene carbonate, while adding PPNCl as cocatalyst to the reaction medium, cyclohexene carbonates were obtained as the main products.
Comparative Study of Aluminum Complexes Bearing N,O- and N,S-Schiff Base in Ring-Opening Polymerization of ε-Caprolactone and l -Lactide
Chang, Meng-Chih,Lu, Wei-Yi,Chang, Heng-Yi,Lai, Yi-Chun,Chiang, Michael Y.,Chen, Hsing-Yin,Chen, Hsuan-Ying
, p. 11292 - 11298 (2015)
A series of Al complexes bearing Schiff base and thio-Schiff base ligands were synthesized, and their application for the ring-opening polymerization of ε-caprolactone (CL) and l-lactide (LA) was studied. It was found that steric effects of the ligands caused higher polymerization rate and most importantly the Al complexes with N,S-Schiff base showed significantly higher polymerization rate than Al complexes with N,O-Schiff base (5-12-fold for CL polymerization and 2-7-fold for LA polymerization). The reaction mechanism of CL polymerization was investigated by density functional theory (DFT). The calculations predicted a lower activation energy for a process involved with an Al complex bearing an N,S-Schiff base ligand (17.6 kcal/mol) than for that of an Al complex bearing an N,O-Schiff base ligand (19.0 kcal/mol), and this magnitude of activation energy reduction is comparable to the magnitude of rate enhancement observed in the experiment. The reduction of activation energy was attributed to the catalyst-substrate destabilization effect. Using a sulfur-containing ligand to decrease the activation energy in the ring-opening polymerization process may be a new strategy to design a new Al complex with high catalytic activity.
An Efficient and Convenient Synthesis of 2-Mercaptobenzaldehyde
Kasmai, Hamid S.,Mischke, Steven G.
, p. 763 - 765 (1989)
An efficient and convenient synthesis of 2-mercaptobenzaldehyde (1) is described.
Synthesis and evaluation of antileishmanial and cytotoxic activity of benzothiopyrane derivatives
Ortiz, Cristian,Echeverri, Fernando,Robledo, Sara,Lanari, Daniela,Curini, Massimo,Qui?ones, Wiston,Vargas, Esteban
, (2020)
In continuation of our efforts to identify promising antileishmanial agents based on the chroman scaffold, we synthesized several substituted 2H-thiochroman derivatives, including thiochromenes, thichromanones and hydrazones substituted in C-2 or C-3 with carbonyl or carboxyl groups. Thirty-two compounds were thus obtained, characterized, and evaluated against intracellular amastigotes of Leishmania (V) panamensis. Twelve compounds were active, with EC50 values lower than 40 μM, but only four compounds displayed the highest antileishmanial activity, with EC50 values below 10 μM; these all compounds possess a good Selectivity Index > 2.6. Although two active compounds were thiochromenes, a clear structure-activity relationship was not detected since each active compound has a different substitution pattern.
Dual-catalyst acceleration of tandem disulfide cleavage and baylis-hillman synthesis of 2 H-1-benzothiopyran derivatives
Nyoni, Dubekile,Lobb, Kevin A.,Kaye, Perry T.
, p. 1837 - 1841 (2013)
While both 1,8-diazabicyclo[5.4.0]undec-7-ene and triphenylphosphine catalyze tandem Baylis-Hillman reaction/disulfide cleavage of 2,2′-dithiodibenzaldehyde independently, when used together as a dual-catalyst system, the overall yields of the cyclized 2H-1-benzothiopyrans are consistently greater and the reaction time decreases dramatically. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.
DEPALMITOYLATING COMPOSITIONS AND THE USE THEREOF
-
Paragraph 0359; 0369; 0371, (2021/02/19)
Disclosed herein, inter alia, are depalmitoylating compounds, compositions, and methods of use thereof.
A cascade deprotonation/intramolecular aldol reaction of α-carbonyl sulfonium ylides with 2-mercaptoindole-3-carbaldehydes and 2-mercaptobenzaldehydes to access thieno[2,3-b]indoles and benzothiophenes
Yang, Lei,Zhou, Shun,Zhao, Jian-Qiang,You, Yong,Wang, Zhen-Hua,Zhou, Ming-Qiang,Yuan, Wei-Cheng
supporting information, p. 3678 - 3686 (2021/05/05)
The first catalyst-free cascade deprotonation/intramolecular aldol reaction of α-carbonyl sulfonium ylides with 2-mercaptoindole-3-carbaldehydes and 2-mercaptobenzaldehydes was developed. A series of thieno[2,3-b]indoles and benzothiophenes were smoothly obtained in high to excellent yields. The salient features of the protocol include catalyst-free conditions, an environment-friendly solvent, broad substrate scope, and large-scale synthesis.
INHIBITORS OF GLUCOSE TRANSPORTERS (GLUTS)
-
Page/Page column 62, (2020/03/29)
The present invention relates to 2,6-methanobenzo[g][1]oxacin-4-onecompounds and their analog compounds and pharmaceutically acceptable salts thereof as selective inhibitor of glucose transporters 1 and 3 (GLUTs 1 and 3), to methods of preparing said compounds, and to the use thereof as pharmaceutically active agents, especially for the prophylaxis and/or treatment of metabolic diseases, immunological diseases, autoimmune diseases, inflammation, graft versus host disease, cancer, and metastasis thereof. Furthermore, the present invention is directed to pharmaceutical composition comprising at least one of 2,6-methanobenzo[g][1]oxacin-4-one compounds and their analog compounds.
High catalytic performance of the first electrospun nano-biohybrid, Mn3O4/copper complex/polyvinyl alcohol, from Amaranthus spinosus plant for biomimetic oxidation reactions
Ekrami-Kakhki, Mehri-Saddat,Naeimi, Atena
, (2020/02/05)
In this study, a novel nano-biocomposite, polyvinylalcohol/Mn3O4/water-soluble copper complex (PVA/Mn3O4/CuWSC), was produced from Amaranthus spinosus. By combining water-soluble copper nanocomplex and Mn3O4 nanoparticles along with polyvinyl alcohols and extracts of this plant, this bio nanomaterial was prepared via electrospinning process. This nanohybrid was characterized using transmission electron microscopy, scanning electron microscopy, atomic force microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, and elemental analysis. Based on its catalytic activities, it is considered a heterogeneous catalyst and is used for the oxidation of alcohols in industrial reactions. It can oxidize the primary and secondary alcohols to corresponding aldehyde and ketone products with high yield and excellent selectivity using H2O2 under solvent-free conditions. The recyclability and reusability of PVA/Mn3O4/CuWSC show that it can be a promising catalyst for clean industrial catalytic applications.
