phenyl (2-(3-(dimethylamino)-1-(4-fluorophenyl)propoxy)pyrimidin-5-yl) carbamate

Base Information

Chemical Name:phenyl (2-(3-(dimethylamino)-1-(4-fluorophenyl)propoxy)pyrimidin-5-yl) carbamate
CAS No.:1584113-99-4
Molecular Formula:C₂₂H₂₃FN₄O₃
Molecular Weight:410.448
Hs Code.:

Synonyms:phenyl (2-(3-(dimethylamino)-1-(4-fluorophenyl)propoxy)pyrimidin-5-yl) carbamate

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Chemical Property of phenyl (2-(3-(dimethylamino)-1-(4-fluorophenyl)propoxy)pyrimidin-5-yl) carbamate

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Technology Process of phenyl (2-(3-(dimethylamino)-1-(4-fluorophenyl)propoxy)pyrimidin-5-yl) carbamate

There total 3 articles about phenyl (2-(3-(dimethylamino)-1-(4-fluorophenyl)propoxy)pyrimidin-5-yl) carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1584113-97-2
2-(3-(dimethylamino)-l-(4-fluorophenyl)propoxy)pyrimidin-5-amine

: 1885-14-9
phenyl chloroformate

: 1584113-99-4
phenyl (2-(3-(dimethylamino)-1-(4-fluorophenyl)propoxy)pyrimidin-5-yl) carbamate

Guidance literature:: With triethylamine; In dichloromethane; at -14 - 20 ℃; for 2h;

Reference yield:

: 1584113-98-3
3-(4-fluorophenyl)-N,N-dimethyl-3-((5-nitropyrimidin-2-yl)oxy)-propan-1-amine

: 1584113-99-4
phenyl (2-(3-(dimethylamino)-1-(4-fluorophenyl)propoxy)pyrimidin-5-yl) carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: platinum(IV) oxide; hydrogen / methanol / 0.67 h / 20 °C

2: triethylamine / dichloromethane / 2 h / -14 - 20 °C

With platinum(IV) oxide; hydrogen; triethylamine; In methanol; dichloromethane;

Reference yield:

: 133712-56-8
3-N,N-dimethylamino-1-(4-fluorophenyl)-propan-1-ol

: 1584113-99-4
phenyl (2-(3-(dimethylamino)-1-(4-fluorophenyl)propoxy)pyrimidin-5-yl) carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 °C / Inert atmosphere

1.2: 4.5 h / 0 - 20 °C

2.1: platinum(IV) oxide; hydrogen / methanol / 0.67 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / -14 - 20 °C

With platinum(IV) oxide; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; mineral oil;