(R)-bambuterol

Base Information

Chemical Name:(R)-bambuterol
CAS No.:788821-30-7
Molecular Formula:C₁₈H₂₉N₃O₅
Molecular Weight:367.445
Hs Code.:
UNII:U44CBZ5I3E
Nikkaji Number:J590.072G
Wikidata:Q27126512
Metabolomics Workbench ID:60451
ChEMBL ID:CHEMBL1337841

Synonyms:(R)-bambuterol;Bambuterol, (R)-;Bambuterol, (-)-;R-Bambuterol;U44CBZ5I3E;UNII-U44CBZ5I3E;CHEBI:59179;(R)-terbutaline bisdimethylcarbamate;(R)-terbutaline bis(dimethylcarbamate);788821-30-7;Carbamic acid, N,N-dimethyl-, 5-((1R)-2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-1,3-phenylene ester;(R)-5-(2-(tert-butylamino)-1-hydroxyethyl)-m-phenylene bis(dimethylcarbamate);5-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diyl bis(dimethylcarbamate);NCGC00016947-01;CAS-81732-46-9;CHEMBL1337841;SCHEMBL13923751;GLXC-25243;[3-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate;Q27126512

Suppliers and Price of (R)-bambuterol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-bambuterol

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:367.21072103
Heavy Atom Count:26
Complexity:446

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)NCC(C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O
Isomeric SMILES:CC(C)(C)NC[C@@H](C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O

Technology Process of (R)-bambuterol

There total 7 articles about (R)-bambuterol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1050279-04-3
(R)-2-[3,5-di(N,N-dimethylcarbamyloxy)phenyl]oxirane

: 75-64-9
tert-butylamine

: 788821-30-7
(R)-2-(tert-butylamino)-1-[3,5-bis(dimethylcarbamoyloxy)phenyl]ethanol

Guidance literature:: for 3h; Reflux;
DOI:10.1016/j.molcatb.2013.08.003

Reference yield:

: (R)-2-chloro-1-[3,5-bis(dimethylcarbamoyloxy)phenyl]-ethanol

: 788821-30-7
(R)-2-(tert-butylamino)-1-[3,5-bis(dimethylcarbamoyloxy)phenyl]ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 0.17 h / 20 °C

2: 3 h / Reflux

With sodium hydroxide; In ethanol; water;
DOI:10.1016/j.molcatb.2013.08.003

Reference yield:

: 35086-59-0
1-(3',5'-diacetoxyphenyl)ethanone

: 788821-30-7
(R)-2-(tert-butylamino)-1-[3,5-bis(dimethylcarbamoyloxy)phenyl]ethanol

Guidance literature:: Multi-step reaction with 7 steps

1: immobilized Burkholderia cepacia lipase (Amano PS-IM) / isopropyl alcohol; tetrahydrofuran / 60 h / 20 °C / Inert atmosphere; Enzymatic reaction

2: potassium carbonate / N,N-dimethyl-formamide / 6.5 h / 20 °C

3: bromine / acetic acid / 1.17 h / 0 - 20 °C

4: sodium chloride / water; acetonitrile / 11.5 h / Reflux

5: whole cells of Williopsis californica JCM 3600 / aq. phosphate buffer; glycerol / 76 h / 30 °C / pH 6.5 / Enzymatic reaction

6: sodium hydroxide / ethanol; water / 0.17 h / 20 °C

7: 3 h / Reflux

With bromine; potassium carbonate; sodium chloride; sodium hydroxide; In tetrahydrofuran; aq. phosphate buffer; ethanol; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; glycerol; acetonitrile;
DOI:10.1016/j.molcatb.2013.08.003