trans-4-(4-{3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

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Chemical Name:trans-4-(4-{3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol
CAS No.:1350425-15-8
Molecular Formula:C₂₆H₂₆ClF₃N₄O₂
Molecular Weight:519.958
Hs Code.:

Synonyms:trans-4-(4-{3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

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Chemical Property of trans-4-(4-{3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

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Technology Process of trans-4-(4-{3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

There total 19 articles about trans-4-(4-{3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₄₇⁽²⁾HClF₃N₄O₄Si

: 1350425-15-8
trans-4-(4-{3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: C₃₇H₄₇⁽²⁾HClF₃N₄O₄Si; With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 23511-05-9
toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester

: 1350425-15-8
trans-4-(4-{3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 100 °C

2.1: water; pyridinium p-toluenesulfonate / acetone / 16 h / 65 °C

3.1: ethanol; sodium tetrahydroborate / 2 h / 20 °C / Inert atmosphere

4.1: dmap; 1H-imidazole / dichloromethane / 0.33 h / 20 °C

5.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.08 h / -78 °C

5.2: 0.5 h / -78 °C

6.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / 20 °C

6.2: 1 h / 20 °C

7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 95 °C

8.1: hydrogenchloride; water / 1,4-dioxane / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; ethanol; water; isopropylmagnesium chloride; pyridinium p-toluenesulfonate; potassium carbonate; caesium carbonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 183208-35-7
5-bromo-1H-pyrrolo[2,3-b]pyridine

: 1350425-15-8
trans-4-(4-{3-[(1S)-1-[2-chloro-6-(difluoromethoxy)-3-fluorophenyl](1-2H)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-5-methyl-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydroxide / methanol / 12 h / 20 °C

2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.5 h / -60 °C

2.2: -60 - 45 °C / Inert atmosphere

3.1: ChiralPak IA / carbon dioxide; methanol / Resolution of racemate

4.1: boron tribromide / dichloromethane / 18.16 h / -78 - 20 °C

4.2: 0.5 h / 0 - 20 °C

5.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

6.1: piperidine / dichloromethane / 32 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 70 °C

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 95 °C

9.1: hydrogenchloride; water / 1,4-dioxane / 20 °C

With piperidine; hydrogenchloride; boron trifluoride diethyl etherate; water; boron tribromide; sodium hydride; potassium carbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; carbon dioxide; water; N,N-dimethyl-formamide;