5-chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethoxy)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Base Information

Chemical Name:5-chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethoxy)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide
CAS No.:1354818-94-2
Molecular Formula:C₂₀H₁₁ClF₄N₄O₄S₂
Molecular Weight:546.91
Hs Code.:

Synonyms:5-chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethoxy)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

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Chemical Property of 5-chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethoxy)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

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Technology Process of 5-chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethoxy)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

There total 3 articles about 5-chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethoxy)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1235407-49-4
2-pyridazin-4-yl-4-(trifluoromethoxy)phenol

: 1235406-85-5
tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate

: 1354818-94-2
5-chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethoxy)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: 2-pyridazin-4-yl-4-(trifluoromethoxy)phenol; tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate; With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 18h;

With hydrogenchloride; In methanol; at 20 ℃; for 18h;

Reference yield:

: 828-27-3
4-Trifluoromethoxyphenol

: 1354818-94-2
5-chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethoxy)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; acetic acid; N-iodo-succinimide / 48 h / 20 °C / Inert atmosphere

2.1: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 45 °C / Inert atmosphere

3.1: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

3.2: 18 h / 20 °C

With N-iodo-succinimide; copper(l) iodide; sulfuric acid; potassium carbonate; acetic acid; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 405517-54-6
2-iodo-4-(trifluoromethoxy) phenol

: 1354818-94-2
5-chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethoxy)phenoxy]-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 45 °C / Inert atmosphere

2.1: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

2.2: 18 h / 20 °C

With copper(l) iodide; potassium carbonate; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dimethyl sulfoxide; N,N-dimethyl-formamide;