(S)-3,5-dichloro-4-(2-(2-(2-(4-(cyclopropylmethoxy)-3-(methylsulfonamido)phenyl)acetoxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(2-(2-(4-(cyclopropylmethoxy)-3-(methylsulfonamido)phenyl)acetoxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide
CAS No.:1428847-66-8
Molecular Formula:C₃₃H₃₄Cl₂F₂N₂O₁₀S
Molecular Weight:759.609
Hs Code.:

(S)-3,5-dichloro-4-(2-(2-(2-(4-(cyclopropylmethoxy)-3-(methylsulfonamido)phenyl)acetoxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Synonyms:(S)-3,5-dichloro-4-(2-(2-(2-(4-(cyclopropylmethoxy)-3-(methylsulfonamido)phenyl)acetoxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

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Chemical Property of (S)-3,5-dichloro-4-(2-(2-(2-(4-(cyclopropylmethoxy)-3-(methylsulfonamido)phenyl)acetoxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

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Technology Process of (S)-3,5-dichloro-4-(2-(2-(2-(4-(cyclopropylmethoxy)-3-(methylsulfonamido)phenyl)acetoxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

There total 10 articles about (S)-3,5-dichloro-4-(2-(2-(2-(4-(cyclopropylmethoxy)-3-(methylsulfonamido)phenyl)acetoxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.9%

: 1428849-79-9
(S)-4-(2-(2-(2-(3-(N-(tert-butoxycarbonyl)-methylsulfonamido)-4-(cyclopropylmethoxy)phenyl)acetoxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide

: 1428847-66-8
(S)-3,5-dichloro-4-(2-(2-(2-(4-(cyclopropylmethoxy)-3-(methylsulfonamido)phenyl)acetoxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1428847-72-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(trityloxy)acetoxy)ethyl)pyridine 1-oxide

: 1428847-66-8
(S)-3,5-dichloro-4-(2-(2-(2-(4-(cyclopropylmethoxy)-3-(methylsulfonamido)phenyl)acetoxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen bromide / dichloromethane / 1 h / 0 - 10 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h

3: hydrogenchloride / dichloromethane / 16 h / 20 °C

With hydrogenchloride; dmap; hydrogen bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

Reference yield:

: 61873-93-6
methyl (4-hydroxy-3-nitrophenyl)acetate

: 1428847-66-8
(S)-3,5-dichloro-4-(2-(2-(2-(4-(cyclopropylmethoxy)-3-(methylsulfonamido)phenyl)acetoxy)acetoxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetonitrile / 1 h / 100 °C / Microwave irradiation

2.1: Adam’s catalyst; hydrogen / methanol / 0.25 h / 1551.49 Torr

3.1: pyridine / 3 h / 20 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

5.2: pH 7

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h

7.1: hydrogenchloride / dichloromethane / 16 h / 20 °C

With pyridine; hydrogenchloride; dmap; Adam’s catalyst; water; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;