6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-pyridinesulfonamide

Base Information

Chemical Name:6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-pyridinesulfonamide
CAS No.:1089669-52-2
Molecular Formula:C₂₄H₂₂F₂N₄O₆S₃
Molecular Weight:596.657
Hs Code.:

Synonyms:6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-pyridinesulfonamide

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Chemical Property of 6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-pyridinesulfonamide

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Technology Process of 6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-pyridinesulfonamide

There total 9 articles about 6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-pyridinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1014613-45-6
[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]boronic acid

: 1089669-43-1
6-chloro-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-pyridinesulfonamide

: 1089669-52-2
6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-pyridinesulfonamide

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: C₂₀H₂₃BF₂N₂O₄S

: 1089669-52-2
6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; water / tetrahydrofuran; hexanes / 0.17 h / -78 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 150 °C / Microwave irradiation

With hydrogenchloride; water; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; hexanes; water;

Reference yield:

: 6684-39-5
2-chloropyridine-5-sulfonyl chloride

: 1089669-52-2
6-[2-(difluoromethyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-3-pyridinesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 19 h / 20 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 150 °C / Microwave irradiation

With sodium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water;