ethyl 3-{4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}propanoate

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Chemical Name:ethyl 3-{4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}propanoate
CAS No.:1195767-08-8
Molecular Formula:C₂₈H₂₇F₃N₄O₄S₂
Molecular Weight:604.674
Hs Code.:

Synonyms:ethyl 3-{4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}propanoate

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Chemical Property of ethyl 3-{4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}propanoate

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Technology Process of ethyl 3-{4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}propanoate

There total 11 articles about ethyl 3-{4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1195768-23-0
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1 ,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

: 193065-68-8
(3-ethoxy-3-oxopropyl)zinc(II) bromide

: 1195767-08-8
ethyl 3-{4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}propanoate

Guidance literature:: bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 206551-41-9
2-fluoro-3-bromobenzoic acid methyl ester

: 1195767-08-8
ethyl 3-{4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: pyridine / dichloromethane / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Cooling with ice-water

5.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C

5.2: 20 - 80 °C

6.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 20 °C

With pyridine; N-Bromosuccinimide; caesium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; toluene;

Reference yield:

: 946126-94-9
2-fluoro-3-nitrobenzoic acid methyl ester

: 1195767-08-8
ethyl 3-{4-[4-(3-{[(2,6-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-2-(1,1-dimethylethyl)-1,3-thiazol-5-yl]-2-pyrimidinyl}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / nickel / tetrahydrofuran; methanol; water / 70 °C

2.1: pyridine / dichloromethane / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Cooling with ice-water

4.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.25 h / 20 °C

4.2: 20 - 80 °C

5.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 20 °C

With pyridine; N-Bromosuccinimide; hydrazine hydrate; lithium hexamethyldisilazane; bis(tri-t-butylphosphine)palladium⁽⁰⁾; nickel; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water;