C₁₅H₈F₃NO₂

Base Information

• Chemical Name: C₁₅H₈F₃NO₂
• CAS No.: 1262725-53-0
• Molecular Formula: C₁₅H₈F₃NO₂
• Molecular Weight: 291.229
• Mol file: 1262725-53-0.mol

Synonyms:C₁₅H₈F₃NO₂

Chemical Property of C₁₅H₈F₃NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₈F₃NO₂

There total 3 articles about C₁₅H₈F₃NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-hydroxy-N-(4-(trifluoromethyl)benzoyl)benzamide (710945-58-7) → C15H8F3NO2 (1262725-53-0)

Guidance literature:

2-hydroxy-N-(4-(trifluoromethyl)benzoyl)benzamide; With sulfuric acid; In acetonitrile; at 90 ℃; for 4h;

With triethylamine; In acetonitrile; at 20 ℃;

Reference yield:

4-trifluoromethylbenzoic acid (455-24-3) + salicylamide (65-45-2) → C15H8F3NO2 (1262725-53-0)

Guidance literature:

With pyridine; thionyl chloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 130 - 140 ℃; for 2h;

DOI:10.1016/j.ejmech.2020.112114

Reference yield:

4-trifluoromethyl-phenyl acetyl chloride (329-15-7) + salicylamide (65-45-2) → C15H8F3NO2 (1262725-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 20 °C

2.1: sulfuric acid / acetonitrile / 4 h / 90 °C

2.2: 20 °C

With sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

upstream raw materials:

4-trifluoromethyl-phenyl acetyl chloride

salicylamide

2-hydroxy-N-(4-(trifluoromethyl)benzoyl)benzamide

4-trifluoromethylbenzoic acid

Downstream raw materials:

C₂₂H₁₄F₃N₃O₂