(αS,5R)-4,5-dihydro-3-(phenylsulfonyl)-α-(phthalylamino)-5-isoxazoleacetic acid

Base Information

Chemical Name:(αS,5R)-4,5-dihydro-3-(phenylsulfonyl)-α-(phthalylamino)-5-isoxazoleacetic acid
CAS No.:91028-60-3
Molecular Formula:C₁₉H₁₄N₂O₇S
Molecular Weight:414.395
Hs Code.:

Synonyms:(αS,5R)-4,5-dihydro-3-(phenylsulfonyl)-α-(phthalylamino)-5-isoxazoleacetic acid

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Chemical Property of (αS,5R)-4,5-dihydro-3-(phenylsulfonyl)-α-(phthalylamino)-5-isoxazoleacetic acid

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Technology Process of (αS,5R)-4,5-dihydro-3-(phenylsulfonyl)-α-(phthalylamino)-5-isoxazoleacetic acid

There total 1 articles about (αS,5R)-4,5-dihydro-3-(phenylsulfonyl)-α-(phthalylamino)-5-isoxazoleacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 70367-23-6
bromo(phenylsulfonyl)formaldoxime

: 85369-51-3
(S)-N-phthalylvinylglycine

: 91028-60-3
(αS,5R)-4,5-dihydro-3-(phenylsulfonyl)-α-(phthalylamino)-5-isoxazoleacetic acid

: 85355-66-4
(αS,5S)-4,5-dihydro-3-(phenylsulfonyl)-α-(phthalylamino)-5-isoxazoleacetic acid

Guidance literature:: With silver nitrate; In tetrahydrofuran; at 50 ℃; for 2.16667h;
DOI:10.1021/jo00159a002

Reference yield: 57.0%

: 91028-60-3
(αS,5R)-4,5-dihydro-3-(phenylsulfonyl)-α-(phthalylamino)-5-isoxazoleacetic acid

: 91028-71-6
(S)-Amino-((R)-3-benzenesulfonyl-4,5-dihydro-isoxazol-5-yl)-acetic acid

Guidance literature:: With hydrazine hydrate; at 50 - 55 ℃; for 7h;
DOI:10.1016/0040-4020(84)85065-6

Reference yield:

: 91028-60-3
(αS,5R)-4,5-dihydro-3-(phenylsulfonyl)-α-(phthalylamino)-5-isoxazoleacetic acid

: (S)-Amino-((R)-3-benzenesulfonyl-4,5-dihydro-isoxazol-5-yl)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / hydrazine hydrate / 7 h / 50 - 55 °C

2: 36 percent / diethyl ether; CH₂Cl₂ / 0.75 h / 0 - 5 °C

With hydrazine hydrate; In diethyl ether; dichloromethane;
DOI:10.1016/0040-4020(84)85065-6