trans-3-(2-(4-(N-tert-butoxycarbonylamino)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:trans-3-(2-(4-(N-tert-butoxycarbonylamino)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:264264-44-0
Molecular Formula:C₂₄H₃₈N₂O₄S
Molecular Weight:450.643
Hs Code.:

Synonyms:trans-3-(2-(4-(N-tert-butoxycarbonylamino)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Chemical Property of trans-3-(2-(4-(N-tert-butoxycarbonylamino)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of trans-3-(2-(4-(N-tert-butoxycarbonylamino)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 6 articles about trans-3-(2-(4-(N-tert-butoxycarbonylamino)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 215790-29-7
trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde

: 123018-23-5
7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 264264-44-0
trans-3-(2-(4-(N-tert-butoxycarbonylamino)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1021/jm030817d

Reference yield:

: 613-73-0
1,2-phenylenediacetonitrile

: 264264-44-0
trans-3-(2-(4-(N-tert-butoxycarbonylamino)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 60 percent / H₂; NH₃ / Raney Ni / ethanol / 24 h / 50 °C / 51714.8 Torr

2.1: triethylamine / CH₂Cl₂ / 18 h / 20 °C

3.1: chlorosulfonic acid / CH₂Cl₂ / 18 h / 20 °C

4.1: sodium sulfite; aq. sodium hydrogen carbonate / tetrahydrofuran / 2 h / 75 °C

4.2: tetrahydrofuran; H₂O / 24 h / 50 °C

5.1: aq. HCl / 18 h / Heating

6.1: 90 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 48 h / 20 °C

With hydrogenchloride; chlorosulfonic acid; ammonia; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine; sodium sulfite; nickel; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm030817d

Reference yield:

: 4424-20-8
2,3,4,5-tetrahydro-1H-3-benzazepine

: 264264-44-0
trans-3-(2-(4-(N-tert-butoxycarbonylamino)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / CH₂Cl₂ / 18 h / 20 °C

2.1: chlorosulfonic acid / CH₂Cl₂ / 18 h / 20 °C

3.1: sodium sulfite; aq. sodium hydrogen carbonate / tetrahydrofuran / 2 h / 75 °C

3.2: tetrahydrofuran; H₂O / 24 h / 50 °C

4.1: aq. HCl / 18 h / Heating

5.1: 90 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 48 h / 20 °C

With hydrogenchloride; chlorosulfonic acid; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine; sodium sulfite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm030817d