trans-3-(2-(4-aminocyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:trans-3-(2-(4-aminocyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:264264-45-1
Molecular Formula:C₁₉H₃₀N₂O₂S
Molecular Weight:350.525
Hs Code.:

Synonyms:trans-3-(2-(4-aminocyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Suppliers and Price of trans-3-(2-(4-aminocyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-3-(2-(4-aminocyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-3-(2-(4-aminocyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 7 articles about trans-3-(2-(4-aminocyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 264264-44-0
trans-3-(2-(4-(N-tert-butoxycarbonylamino)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 264264-45-1
trans-3-(2-(4-aminocyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm030817d

Reference yield:

: 613-73-0
1,2-phenylenediacetonitrile

: 264264-45-1
trans-3-(2-(4-aminocyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 60 percent / H₂; NH₃ / Raney Ni / ethanol / 24 h / 50 °C / 51714.8 Torr

2.1: triethylamine / CH₂Cl₂ / 18 h / 20 °C

3.1: chlorosulfonic acid / CH₂Cl₂ / 18 h / 20 °C

4.1: sodium sulfite; aq. sodium hydrogen carbonate / tetrahydrofuran / 2 h / 75 °C

4.2: tetrahydrofuran; H₂O / 24 h / 50 °C

5.1: aq. HCl / 18 h / Heating

6.1: 90 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 48 h / 20 °C

7.1: trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With hydrogenchloride; chlorosulfonic acid; ammonia; hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; sodium sulfite; nickel; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm030817d

Reference yield:

: 4424-20-8
2,3,4,5-tetrahydro-1H-3-benzazepine

: 264264-45-1
trans-3-(2-(4-aminocyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / CH₂Cl₂ / 18 h / 20 °C

2.1: chlorosulfonic acid / CH₂Cl₂ / 18 h / 20 °C

3.1: sodium sulfite; aq. sodium hydrogen carbonate / tetrahydrofuran / 2 h / 75 °C

3.2: tetrahydrofuran; H₂O / 24 h / 50 °C

4.1: aq. HCl / 18 h / Heating

5.1: 90 percent / sodium triacetoxyborohydride / CH₂Cl₂ / 48 h / 20 °C

6.1: trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With hydrogenchloride; chlorosulfonic acid; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; sodium sulfite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm030817d