N-Boc-3-Ethylpiperazine

Base Information

• Chemical Name: N-Boc-3-Ethylpiperazine
• CAS No.: 438049-35-5
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.30
• Hs Code.: 2933599090
• Mol file: 438049-35-5.mol

Synonyms:3-Ethyl-piperazine-1-carboxylicacid tert-butyl ester;2-Methyl-2-propanyl 3-ethyl-1-piperazinecarboxylate;tert-Butyl 3-ethylpiperazine-1-carboxylate;

Chemical Property of N-Boc-3-Ethylpiperazine

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.457
• Boiling Point: 286.708 °C at 760 mmHg
• PKA: 8.52±0.40(Predicted)
• Flash Point: 127.197 °C
• PSA: 41.57000
• Density: 0.982 g/cm³
• LogP: 1.87200
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl3-ethylpiperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Boc-3-Ethylpiperazine

There total 4 articles about N-Boc-3-Ethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethylpiperazine dihydrochloride (128427-05-4,438050-07-8) + di-tert-butyl dicarbonate (24424-99-5) → 3-ethylpiperazine-1-carboxylic acid tert-butyl ester (438049-35-5,438050-08-9)

Guidance literature:

With triethylamine; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-ethylpiperazine dihydrobromide → 3-ethylpiperazine-1-carboxylic acid tert-butyl ester (438049-35-5,438050-08-9)

Guidance literature:

With triethylamine; In methanol; for 16h;

Reference yield:

C12H22N2O5 (1332870-48-0) → 3-ethylpiperazine-1-carboxylic acid tert-butyl ester (438049-35-5,438050-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol

1.2: Reflux

2.1: borane-THF / tetrahydrofuran / Reflux

3.1: triethylamine / methanol / 16 h

With hydrogenchloride; borane-THF; triethylamine; In tetrahydrofuran; methanol; ethanol;

upstream raw materials:

2-ethylpiperazine dihydrochloride

di-tert-butyl dicarbonate

C₁₂H₂₂N₂O₅

Downstream raw materials:

(+/-)4-difluoromethoxybenzyl-2-ethyl-4-tert-butoxycarbonylpiperazine-1-carboxylate

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