[1-(4-fluorophenyl)cyclobutyl]methanamine

Base Information

• Chemical Name: [1-(4-fluorophenyl)cyclobutyl]methanamine
• CAS No.: 1017462-08-6
• Molecular Formula: C₁₁H₁₄FN
• Molecular Weight: 179.237
• Hs Code.: 2922290090
• Mol file: 1017462-08-6.mol

Synonyms:(1-(4-fluorophenyl)cyclobutyl)methanamine

Chemical Property of [1-(4-fluorophenyl)cyclobutyl]methanamine

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(4-Fluorophenyl)-cyclobutanemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [1-(4-fluorophenyl)cyclobutyl]methanamine

There total 2 articles about [1-(4-fluorophenyl)cyclobutyl]methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

1-(4-fluorophenyl)cyclobutane-1-carbonitrile (405090-30-4) → (1-(4-fluorophenyl)cyclobutyl)methanamine (1017462-08-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 2h;

Reference yield:

4-fluorophenylacetonitrile (459-22-3) → (1-(4-fluorophenyl)cyclobutyl)methanamine (1017462-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C / Cooling with ice

2: ammonium hydroxide; hydrogen / ethanol / 23 h / 20 °C

With ammonium hydroxide; hydrogen; sodium hydride; In ethanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.bmc.2011.07.030

Reference yield: 52.0%

3,6-dichlorpyridazine (141-30-0) + (1-(4-fluorophenyl)cyclobutyl)methanamine (1017462-08-6) → 6-chloro-N-((1-(4-fluorophenyl)cyclobutyl)methyl)pyridazin-3-amine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 175 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.1c01067

upstream raw materials:

1-(4-fluorophenyl)cyclobutane-1-carbonitrile

4-fluorophenylacetonitrile

Downstream raw materials:

1-benzyl-N-{[1-(4-fluorophenyl)cyclobutyl]methyl}piperidine-4-carboxamide hydrochloride

N-{[1-(4-fluorophenyl)cyclobutyl]methyl}-3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzamide

Refernces

• 1、 Watanuki, Susumu,Matsuura, Keisuke,Tomura, Yuichi,Okada, Minoru,Okazaki, Toshio,Ohta, Mitsuaki,Tsukamoto, Shin-Ichi. "Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4- fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents". experimental part. p. 5628 - 5638. Retrieved 2011/10/12.