4-(N-benzyl-N-methyl)amino-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-fluoro-2-methoxybenzamide

Base Information

Chemical Name:4-(N-benzyl-N-methyl)amino-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-fluoro-2-methoxybenzamide
CAS No.:483305-03-9
Molecular Formula:C₂₄H₃₃FN₄O₂
Molecular Weight:428.55
Hs Code.:

Synonyms:4-(N-benzyl-N-methyl)amino-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-fluoro-2-methoxybenzamide

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Chemical Property of 4-(N-benzyl-N-methyl)amino-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-fluoro-2-methoxybenzamide

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Technology Process of 4-(N-benzyl-N-methyl)amino-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-fluoro-2-methoxybenzamide

There total 7 articles about 4-(N-benzyl-N-methyl)amino-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-fluoro-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 124-41-4
sodium methylate

: 483305-02-8
4-(N-benzyl-N-methyl)amino-2,5-difluoro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)benzamide

: 483305-03-9
4-(N-benzyl-N-methyl)amino-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-fluoro-2-methoxybenzamide

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 15h;
DOI:10.1248/cpb.50.941

Reference yield:

: 111-37-5
N-methyl-N'-ethylethane-1,2-diamine

: 483305-03-9
4-(N-benzyl-N-methyl)amino-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-fluoro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 3 h / 5 °C

1.2: 46 percent / NaBH₄ / methanol / 16 h / 20 °C

2.1: 88 percent / HBr / acetic acid / 1 h / 20 °C

3.1: 56 percent / EDC / CH₂Cl₂ / 4 h / 20 °C

4.1: 77 percent / dimethylformamide / 15 h / 120 °C

With hydrogen bromide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.50.941

Reference yield:

: 446-17-3
2,4,5-trifluorobenzoic acid

: 483305-03-9
4-(N-benzyl-N-methyl)amino-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-5-fluoro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 49 percent / Et₃N; pyridine / 45 h / Heating

2: 56 percent / EDC / CH₂Cl₂ / 4 h / 20 °C

3: 77 percent / dimethylformamide / 15 h / 120 °C

With pyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.50.941