4-(1-(Tert-butoxycarbonyl)piperidin-4-yl)butanoic acid

Base Information

Chemical Name:4-(1-(Tert-butoxycarbonyl)piperidin-4-yl)butanoic acid
CAS No.:142247-38-9
Molecular Formula:C14H25NO4
Molecular Weight:271.357
Hs Code.:29333990
European Community (EC) Number:675-750-0
DSSTox Substance ID:DTXSID30439344
Wikidata:Q72450498
Mol file:142247-38-9.mol

Synonyms:142247-38-9;4-(1-(tert-butoxycarbonyl)piperidin-4-yl)butanoic acid;N-Boc-(4-piperidin-4-yl)butyric acid;4-(1-boc-piperidin-4-yl)butanoic acid;N-Boc-4-Piperidin-4-yl-butyric acid;N-BOC-4-PIPERIDINEBUTANOIC ACID;1-boc-4-(3-carboxy-propyl)-piperidine;4-(1-boc-piperidine-4-yl)-butanoic acid;4-(1-boc-piperidin-4-yl)-butanoic acid;4-(3-carboxy-propyl)-piperidine-1-carboxylic acid tert-butyl ester;4-PIPERIDINEBUTANOIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-;1-Boc-4-piperidinebutanoic acid;MFCD04114965;4-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]butanoic acid;4-[1-(tert-butoxycarbonyl)piperidin-4-yl]butanoic acid;SCHEMBL544238;DTXSID30439344;OAFRZYWOCMCWMM-UHFFFAOYSA-N;AMY21110;4-(N-BOC-4-piperidyl)butanoic acid;AKOS015837027;AB19345;AC-6323;CS-W003175;DS-16296;SY021793;FT-0643340;EN300-1877290;4-(1-t-butyloxycarbonyl-4-piperidyl)butanoic acid;J-523488;4-(1-(tert-butoxycarbonyl)piperidin-4-yl)butanoicacid;4-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}butanoic acid;4-(3-carboxypropyl)piperidine-1-carboxylic acid tert-butyl ester;N-BOC-4-PIPERIDIN-4-YL-BUTYRIC ACID

Suppliers and Price of 4-(1-(Tert-butoxycarbonyl)piperidin-4-yl)butanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-Boc-4-Piperidin-4-yl-butyricAcid
50mg
$ 60.00

Matrix Scientific
4-(1-Boc-piperidine-4-yl)-butanoic acid
1g
$ 220.00

Matrix Scientific
4-(1-Boc-piperidine-4-yl)-butanoic acid
5g
$ 440.00

Matrix Scientific
4-(1-Boc-piperidine-4-yl)-butanoic acid
10g
$ 640.00

J&W Pharmlab
1-Boc-4-(3-carboxy-propyl)-piperidine 97%
25g
$ 1998.00

J&W Pharmlab
1-Boc-4-(3-carboxy-propyl)-piperidine 97%
5g
$ 598.00

J&W Pharmlab
1-Boc-4-(3-carboxy-propyl)-piperidine 97%
1g
$ 198.00

Crysdot
4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)butanoicacid 97%
5g
$ 119.00

Chemenu
4-(1-Boc-piperidine-4-yl)-butanoicacid 97%
5g
$ 118.00

Chemenu
4-(1-Boc-piperidine-4-yl)-butanoicacid 97%
10g
$ 212.00

Total 39 raw suppliers

Chemical Property of 4-(1-(Tert-butoxycarbonyl)piperidin-4-yl)butanoic acid

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.485
Boiling Point:399.668 °C at 760 mmHg
PKA:4.82±0.10(Predicted)
Flash Point:195.512 °C
PSA：66.84000
Density:1.086 g/cm³
LogP:2.82630
Storage Temp.:Store at 0-5°C
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:271.17835828
Heavy Atom Count:19
Complexity:314

Purity/Quality:

98% ^*data from raw suppliers

N-Boc-4-Piperidin-4-yl-butyricAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)CCCC(=O)O

Technology Process of 4-(1-(Tert-butoxycarbonyl)piperidin-4-yl)butanoic acid

There total 20 articles about 4-(1-(Tert-butoxycarbonyl)piperidin-4-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 142355-82-6
methyl 4-piperidin-4-yl>butanoate

: 142247-38-9
4-[1-(tert-butoxycarbonyl)piperidin-4-yl]butanoic acid

Guidance literature:: With sodium hydroxide; In methanol;
DOI:10.1021/jm00042a007

Reference yield: 59.0%

: 180307-56-6
tert-butyl 4-ethenylpiperidine-1-carboxylate

: 79-08-3
bromoacetic acid

: 142247-38-9
4-[1-(tert-butoxycarbonyl)piperidin-4-yl]butanoic acid

Guidance literature:: With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; diphenyldisulfane; trifluoroacetic acid; In 1,4-dioxane; at 20 ℃; for 20h; Sealed tube; Inert atmosphere; Irradiation;

Reference yield:

: 100-43-6,329041-72-7
4-vinylpyridine

: 142247-38-9
4-[1-(tert-butoxycarbonyl)piperidin-4-yl]butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) EtOH, 80 deg C, 30 min, 2.) EtOH, 80 deg C, 3 h

2: 20percent aq. HCl / 16 h / Heating

3: H₂, AcOH / PtO₂ / methanol / 16 h / 2585.7 Torr

4: 1 N aq. NaOH / tetrahydrofuran / 16 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; sodium hydride; acetic acid; platinum(IV) oxide; In tetrahydrofuran; methanol;
DOI:10.1021/jm9801096