6-Bromo-5-amino-2-picoline

Base Information

• Chemical Name: 6-Bromo-5-amino-2-picoline
• CAS No.: 126325-48-2
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.039
• Hs Code.: 2933399090
• Mol file: 126325-48-2.mol

Synonyms:3-Amino-2-bromo-6-methylpyridine;4-bromo-2-methylpyridin-3-amine;

Chemical Property of 6-Bromo-5-amino-2-picoline

Chemical Property:

• Boiling Point: 287 °C at 760 mmHg
• PKA: 4.91±0.10(Predicted)
• Flash Point: 127.4 °C
• PSA: 38.91000
• Density: 1.593 g/cm³
• LogP: 2.31590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

4-bromo-2-methylpyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Amino-2-bromo-6-picoline is used in the synthesis of selective CB2 agonists.

Technology Process of 6-Bromo-5-amino-2-picoline

There total 1 articles about 6-Bromo-5-amino-2-picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

2-methyl-3-pyridinamine (3430-10-2) → 3-amino-6-bromo-2-methylpyridine (126325-47-1) + 3-amino-4-bromo-2-methylpyridine (126325-48-2) + 3-amino-4,6-dibromo-2-methylpyridine

Guidance literature:

With hydrogen bromide; dihydrogen peroxide; at 70 ℃; for 1h; Product distribution;

Reference yield:

3-amino-4-bromo-2-methylpyridine (126325-48-2) → 7-bromo-1H-pyrazolo[4,3-b]pyridine (1256806-33-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap / 60 °C

2.1: sodium hydroxide / methanol / 0.5 h / 20 °C

3.1: acetic anhydride; potassium acetate / toluene / 0.25 h

3.2: 4 h / 85 °C

With dmap; potassium acetate; acetic anhydride; sodium hydroxide; In methanol; toluene;

upstream raw materials:

2-methyl-3-pyridinamine

Downstream raw materials:

7-bromo-1H-pyrazolo[4,3-b]pyridine

Refernces