1H-Pyrazolo[4,3-b]pyridine, 7-broMo-

Base Information

• Chemical Name: 1H-Pyrazolo[4,3-b]pyridine, 7-broMo-
• CAS No.: 1256806-33-3
• Molecular Formula: C₆H₄BrN₃
• Molecular Weight: 198.022
• Hs Code.: 2933990090
• Mol file: 1256806-33-3.mol

Synonyms:1H-Pyrazolo[4,3-b]pyridine, 7-broMo-;7-broMo-1H-pyrazolo[4

Chemical Property of 1H-Pyrazolo[4,3-b]pyridine, 7-broMo-

Chemical Property:

• Boiling Point: 356.2±22.0 °C(Predicted)
• PKA: 8.76±0.40(Predicted)
• PSA: 41.57000
• Density: 1.894±0.06 g/cm3(Predicted)
• LogP: 1.72040

Purity/Quality:

97% ^*data from raw suppliers

7-Bromo-1H-pyrazolo[4,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazolo[4,3-b]pyridine, 7-broMo-

There total 7 articles about 1H-Pyrazolo[4,3-b]pyridine, 7-broMo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.35%

N-(4-bromo-2-methylpyridin-3-yl)acetamide (1350648-86-0) → 7-bromo-1H-pyrazolo[4,3-b]pyridine (1256806-33-3)

Guidance literature:

N-(4-bromo-2-methylpyridin-3-yl)acetamide; With potassium acetate; acetic anhydride; In toluene; for 0.25h;

With isopentyl nitrite; In toluene; at 85 ℃; for 4h;

Reference yield:

2-methyl-3-nitro-4-pyridinol (18614-66-9) → 7-bromo-1H-pyrazolo[4,3-b]pyridine (1256806-33-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: phosphorus(V) oxybromide / 3 h / 140 °C / pressure vessel

2.1: hydrogenchloride; tin(II) chloride dihdyrate / water / 1 h / 40 °C

3.1: dmap / 60 °C

4.1: sodium hydroxide / methanol / 0.5 h / 20 °C

5.1: acetic anhydride; potassium acetate / toluene / 0.25 h

5.2: 4 h / 85 °C

With hydrogenchloride; dmap; tin(II) chloride dihdyrate; potassium acetate; acetic anhydride; sodium hydroxide; phosphorus(V) oxybromide; In methanol; water; toluene;

Reference yield:

3-methyl-4-pyridinamine (18437-58-6) → 7-bromo-1H-pyrazolo[4,3-b]pyridine (1256806-33-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: nitric acid; sodium nitrite / water / -17 - 0 °C

2.1: nitric acid; sulfuric acid / 25 - 130 °C

3.1: phosphorus(V) oxybromide / 3 h / 140 °C / pressure vessel

4.1: hydrogenchloride; tin(II) chloride dihdyrate / water / 1 h / 40 °C

5.1: dmap / 60 °C

6.1: sodium hydroxide / methanol / 0.5 h / 20 °C

7.1: acetic anhydride; potassium acetate / toluene / 0.25 h

7.2: 4 h / 85 °C

With hydrogenchloride; dmap; tin(II) chloride dihdyrate; sulfuric acid; nitric acid; potassium acetate; acetic anhydride; sodium hydroxide; sodium nitrite; phosphorus(V) oxybromide; In methanol; water; toluene;

upstream raw materials:

2-methyl-3-nitro-4-pyridinol

3-methyl-4-pyridinamine

2-Methyl-4-hydroxypyridine

4-bromo-2-methyl-3-nitropyridine