methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate monohydrochloride

Base Information

• Chemical Name: methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate monohydrochloride
• CAS No.: 1314097-37-4
• Molecular Formula: C₁₈H₁₈ClNO₄S*ClH
• Molecular Weight: 416.325
• Mol file: 1314097-37-4.mol

Synonyms:methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate monohydrochloride

Chemical Property of methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate monohydrochloride

There total 7 articles about methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate (1314081-53-2) → methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate monohydrochloride (1314097-37-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; ethanol; at -10 ℃; for 0.0833333h; pH=2;

Reference yield:

Isopropenyl acetate (108-22-5) + 2-Oxoclopidogrel (1147350-75-1,109904-27-0) → methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate monohydrochloride (1314097-37-4)

Guidance literature:

Isopropenyl acetate; 2-Oxoclopidogrel; With toluene-4-sulfonic acid; at 90 ℃; for 6h;

With hydrogenchloride; In acetone; Product distribution / selectivity; Cooling;

Reference yield:

(R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester → methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate monohydrochloride (1314097-37-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / dichloromethane; water / 0.17 h

1.2: 1 h / Reflux

2.1: toluene-4-sulfonic acid / 6 h / 90 °C

2.2: Cooling

With potassium carbonate; toluene-4-sulfonic acid; In dichloromethane; water;

upstream raw materials:

(R)-2-chloromandelic acid

Isopropenyl acetate

2-Oxoclopidogrel

methyl (R)-2-chloromandelate