Vicagrel

Base Information

Chemical Name:Vicagrel
CAS No.:1314081-53-2
Molecular Formula:C₁₈H₁₈ClNO₄S
Molecular Weight:379.864
Hs Code.:
UNII:8A63K3TN0U
Nikkaji Number:J3.596.468A
ChEMBL ID:CHEMBL2042273

Synonyms:methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate;vicagrel

Suppliers and Price of Vicagrel

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Vicagrel

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:379.0645069
Heavy Atom Count:25
Complexity:506

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3Cl)C(=O)OC
Isomeric SMILES:CC(=O)OC1=CC2=C(S1)CCN(C2)[C@@H](C3=CC=CC=C3Cl)C(=O)OC
Recent ClinicalTrials:PK/PD Study of Vicagrel and Clopidogrel in Healthy Subjects With Different CYP2C19 Metabolizers

Technology Process of Vicagrel

There total 5 articles about Vicagrel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.2%

: 1147350-75-1,109904-27-0
2-Oxoclopidogrel

: 108-24-7
acetic anhydride

: 1314081-53-2
methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate

Guidance literature:: With triethylamine; In acetonitrile; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm300038c

Reference yield: 93.0%

: 1314081-53-2
methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate

Guidance literature:

Reference yield:

: (R)-2-(2-chlorophenyl)-2-(4-nitrobenzenesulfonyloxy)acetic acid methyl ester

: 1314081-53-2
methyl (S,E)-2-(2-chlorophenyl)-2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydrogencarbonate / acetonitrile / 26 h / 20 °C / Inert atmosphere

2: triethylamine / acetonitrile / 2 h / 0 - 20 °C

With potassium hydrogencarbonate; triethylamine; In acetonitrile;
DOI:10.1021/jm300038c