[2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphonic acid dimethyl ester

Base Information

Chemical Name:[2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphonic acid dimethyl ester
CAS No.:870822-51-8
Molecular Formula:C₁₁H₁₃ClF₃O₃P
Molecular Weight:316.644
Hs Code.:

Synonyms:[2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphonic acid dimethyl ester

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Chemical Property of [2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphonic acid dimethyl ester

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Technology Process of [2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphonic acid dimethyl ester

There total 1 articles about [2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 756-79-6
dimethyl methane phosphonate

: 870822-51-8
[2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphonic acid dimethyl ester

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; cooling;

4-chloro-3-trifluoromethylbenzyl halide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 16h;
DOI:10.1016/j.bmc.2005.07.056

Reference yield: 83.0%

: 870822-51-8
[2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphonic acid dimethyl ester

: 870822-56-3
[2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphonic acid

Guidance literature:: With hydrogenchloride; for 16h; Heating;
DOI:10.1016/j.bmc.2005.07.056

Reference yield:

: 870822-51-8
[2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphonic acid dimethyl ester

: C₂₃H₁₈Cl₂F₃O₂P

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / HCl / 16 h / Heating

2: thionyl chloride; DMF / 3.5 h / Heating

3: 5-ethylthio-1H-tetrazole; ethyldiisopropylamine / benzene / 2.5 h / 20 °C

With hydrogenchloride; thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; 5-(ethylthio)-1H-tetrazole; In benzene;
DOI:10.1016/j.bmc.2005.07.056