N-{[(9H-fluoren-9-yl)methoxy][2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphinyl}-L-glutamic acid dimethyl ester

Base Information

Chemical Name:N-{[(9H-fluoren-9-yl)methoxy][2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphinyl}-L-glutamic acid dimethyl ester
CAS No.:870822-61-0
Molecular Formula:C₃₀H₃₀ClF₃NO₆P
Molecular Weight:623.993
Hs Code.:

Synonyms:N-{[(9H-fluoren-9-yl)methoxy][2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphinyl}-L-glutamic acid dimethyl ester

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Chemical Property of N-{[(9H-fluoren-9-yl)methoxy][2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphinyl}-L-glutamic acid dimethyl ester

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Technology Process of N-{[(9H-fluoren-9-yl)methoxy][2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphinyl}-L-glutamic acid dimethyl ester

There total 4 articles about N-{[(9H-fluoren-9-yl)methoxy][2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphinyl}-L-glutamic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₁₈Cl₂F₃O₂P

: 6525-53-7,16422-27-8,40149-68-6
L-glutamic acid dimethyl ester

: 870822-61-0
N-{[(9H-fluoren-9-yl)methoxy][2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphinyl}-L-glutamic acid dimethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In benzene; at 0 - 20 ℃; for 17h;
DOI:10.1016/j.bmc.2005.07.056

Reference yield:

: C₉H₇Cl₃F₃OP

: 870822-61-0
N-{[(9H-fluoren-9-yl)methoxy][2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphinyl}-L-glutamic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 5-ethylthio-1H-tetrazole; ethyldiisopropylamine / benzene / 2.5 h / 20 °C

2: ethyldiisopropylamine / benzene / 17 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; 5-(ethylthio)-1H-tetrazole; In benzene;
DOI:10.1016/j.bmc.2005.07.056

Reference yield:

: 870822-51-8
[2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphonic acid dimethyl ester

: 870822-61-0
N-{[(9H-fluoren-9-yl)methoxy][2-(4-chloro-3-trifluoromethylphenyl)ethyl]phosphinyl}-L-glutamic acid dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / HCl / 16 h / Heating

2: thionyl chloride; DMF / 3.5 h / Heating

3: 5-ethylthio-1H-tetrazole; ethyldiisopropylamine / benzene / 2.5 h / 20 °C

4: ethyldiisopropylamine / benzene / 17 h / 0 - 20 °C

With hydrogenchloride; thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; 5-(ethylthio)-1H-tetrazole; In benzene;
DOI:10.1016/j.bmc.2005.07.056