1-Bromoisoquinoline

Base Information

• Chemical Name: 1-Bromoisoquinoline
• CAS No.: 1532-71-4
• Molecular Formula: C9H6BrN
• Molecular Weight: 208.057
• Hs Code.: 29334900
• Mol file: 1532-71-4.mol

Synonyms:5-(Piperazine-1-sulfonyl)-isoquinoline; hydrochloride

Chemical Property of 1-Bromoisoquinoline

Chemical Property:

• Appearance/Colour: Pale yellow solid
• Vapor Pressure: 0.000768mmHg at 25°C
• Melting Point: 42.0 to 46.0 °C
• Refractive Index: 1.673
• Boiling Point: 316.3 °C at 760 mmHg
• PKA: 2.03±0.30(Predicted)
• Flash Point: 145.1 °C
• PSA: 12.89000
• Density: 1.564 g/cm³
• LogP: 2.99730
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Bromoisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25-41
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Useful:

Refernces

A REGIOSPECIFIC TOTAL SYNTHESIS OF ELLIPTICINE VIA NITRENE INSERTION

10.1016/S0040-4039(00)95184-0

The research focuses on the regiospecific total synthesis of ellipticine, a 6H-pyrido[4,3-b]carbazole alkaloid with significant anticancer activity. The purpose of the study was to develop a general synthetic approach that would allow for the preparation of a number of ellipticine derivatives. The researchers achieved this by employing a versatile coupling reaction between phenylboronic acid and a substituted bromoisoquinoline, followed by carbazole ring formation via a nitrene insertion reaction. This method successfully yielded ellipticine, and the synthesized compound was confirmed through satisfactory spectroscopic (nmr and ir) and analytical (elemental and/or mass spectral) data. The conclusion of the research was the successful completion of a general and regiospecific synthesis route for ellipticine, which could potentially be adapted for the synthesis of other related alkaloids.