A REGIOSPECIFIC TOTAL SYNTHESIS OF ELLIPTICINE VIA NITRENE INSERTION

DOI: 10.1016/S0040-4039(00)95184-0

Source and publish data:

Tetrahedron Letters p. 297 - 300 (1989)

Update date:2022-09-26

Topics: Total synthesis Regiospecific Ellipticine

Authors:

Miller, R. Bryan

Dugar, Sundeep

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Article abstract of DOI:10.1016/S0040-4039(00)95184-0

Ellipticine, a 6H-pyrido<4,3-b>carbazole alkaloid, has been regiospecifically synthesized by a general route which should allow for the preparation of a number of derivatives.The approach employs a versatile coupling reaction between phenylboronic acid and a substituted bromoisoquinoline followed by carbazole ring formation via a nitrene insertion reaction to give ellipticine.

Full text of DOI:10.1016/S0040-4039(00)95184-0

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