Technology Process of 1-(2-aminophenyl)-7-(benzyloxy)-3,3-diethylindoline-4-carbonitrile
There total 4 articles about 1-(2-aminophenyl)-7-(benzyloxy)-3,3-diethylindoline-4-carbonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
1.2: 24 h / 20 °C
2.1: sodium nitrite; hydrogenchloride / water / 0.33 h / -10 - 0 °C
3.1: sulfuric acid / ethanol / 72 h / 0 - 20 °C
3.2: 0.75 h / -10 - 20 °C
4.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 66 h / 120 °C / Inert atmosphere; Sealed tube
4.2: 2 h / 20 °C
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); sulfuric acid; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium nitrite;
In
ethanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sulfuric acid / ethanol / 72 h / 0 - 20 °C
1.2: 0.75 h / -10 - 20 °C
2.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 66 h / 120 °C / Inert atmosphere; Sealed tube
2.2: 2 h / 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); sulfuric acid; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
ethanol; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium nitrite; hydrogenchloride / water / 0.33 h / -10 - 0 °C
2.1: sulfuric acid / ethanol / 72 h / 0 - 20 °C
2.2: 0.75 h / -10 - 20 °C
3.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 66 h / 120 °C / Inert atmosphere; Sealed tube
3.2: 2 h / 20 °C
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); sulfuric acid; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium nitrite;
In
ethanol; water; toluene;
