(2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester
CAS No.:350246-27-4
Molecular Formula:C₃₆H₄₆N₂O₇SeSi
Molecular Weight:725.816
Hs Code.:

(2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester

Synonyms:(2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester

Suppliers and Price of (2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester

There total 14 articles about (2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 51694-22-5
ortho-nitrophenyl selenocyanate

: 350246-26-3
(2S,3S,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester

: 350246-27-4
(2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: With tributylphosphine; In tetrahydrofuran;
DOI:10.1016/S0040-4039(98)02618-5

Reference yield:

: 22927-31-7
4-oxobutyl benzoate

: 350246-27-4
(2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: MgSO₄ / CH₂Cl₂ / 1 h / 0 °C

2: 2.25 g / toluene / 24 h / 70 °C

3: H₂ / 20percent Pd/C / methanol / 48 h

4: 2.88 g / NaHCO₃ / diethyl ether / 20 h / 0 °C

5: 72 percent / nBu₃P / tetrahydrofuran / 2 h

With tributylphosphine; hydrogen; sodium hydrogencarbonate; magnesium sulfate; 20percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1002/1521-3765(20010504)7:9<1845::AID-CHEM1845>3.0.CO;2-2

Reference yield:

: 220861-37-0
(R)-tert-butyl 3-hydroxypent-4-enoate

: 350246-27-4
(2S,3R,4R)-2-(3-Benzoyloxy-propyl)-4-(tert-butyl-dimethyl-silanyloxy)-3-(2-nitro-phenylselanylmethyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / imidazole / CH₂Cl₂ / 4 h

2: 79 percent / DIBAL / hexane; toluene / 0.5 h / -78 °C

3: 98 percent / H₂NOH*HCl / aq. ethanol / 14 h / 20 °C

4: sodium cyanoborohydride; HCl / methanol / 0.5 h / -10 °C

5: MgSO₄ / CH₂Cl₂ / 1 h / 0 °C

6: 2.25 g / toluene / 24 h / 70 °C

7: H₂ / 20percent Pd/C / methanol / 48 h

8: 2.88 g / NaHCO₃ / diethyl ether / 20 h / 0 °C

9: 72 percent / nBu₃P / tetrahydrofuran / 2 h

With 1H-imidazole; hydrogenchloride; tributylphosphine; hydroxylamine hydrochloride; hydrogen; diisobutylaluminium hydride; sodium cyanoborohydride; sodium hydrogencarbonate; magnesium sulfate; 20percent Pd/C; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; toluene;
DOI:10.1002/1521-3765(20010504)7:9<1845::AID-CHEM1845>3.0.CO;2-2