(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-yl)(3-chloro-4,5-dihydroxyphenyl)methanone

Base Information

Chemical Name:(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-yl)(3-chloro-4,5-dihydroxyphenyl)methanone
CAS No.:1431545-75-3
Molecular Formula:C₂₀H₂₁ClN₂O₄
Molecular Weight:388.851
Hs Code.:

Synonyms:(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-yl)(3-chloro-4,5-dihydroxyphenyl)methanone

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Chemical Property of (5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-yl)(3-chloro-4,5-dihydroxyphenyl)methanone

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Technology Process of (5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-yl)(3-chloro-4,5-dihydroxyphenyl)methanone

There total 6 articles about (5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-yl)(3-chloro-4,5-dihydroxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: C₂₅H₂₉ClN₂O₆

: 1431545-75-3
(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-yl)(3-chloro-4,5-dihydroxyphenyl)methanone

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1411994-27-8
C₂₁H₂₄N₂O₃

: 1431545-75-3
(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-yl)(3-chloro-4,5-dihydroxyphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Autoclave

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

4: boron tribromide / dichloromethane / 1 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; boron tribromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;

Reference yield:

: 1411992-97-6
benzyl-5-cyano-2H-spiro[benzofuran-3,4′-piperidine]-1′-carboxylate

: 1431545-75-3
(5-(aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-yl)(3-chloro-4,5-dihydroxyphenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: methanol; sodium tetrahydroborate; nickel dichloride / 0 - 20 °C

2: 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Autoclave

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

5: boron tribromide / dichloromethane / 1 h / 20 °C

With methanol; dmap; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; boron tribromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; nickel dichloride; In methanol; dichloromethane;