benzyl 5-((tert-butoxycarbonyl)aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-carboxylate

Base Information

Chemical Name:benzyl 5-((tert-butoxycarbonyl)aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-carboxylate
CAS No.:1411992-98-7
Molecular Formula:C₂₆H₃₂N₂O₅
Molecular Weight:452.55
Hs Code.:

Synonyms:benzyl 5-((tert-butoxycarbonyl)aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-carboxylate

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Chemical Property of benzyl 5-((tert-butoxycarbonyl)aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-carboxylate

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Technology Process of benzyl 5-((tert-butoxycarbonyl)aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-carboxylate

There total 5 articles about benzyl 5-((tert-butoxycarbonyl)aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.7%

: 24424-99-5
di-tert-butyl dicarbonate

: 1411992-97-6
benzyl-5-cyano-2H-spiro[benzofuran-3,4′-piperidine]-1′-carboxylate

: 1411992-98-7
benzyl 5-((tert-butoxycarbonyl)aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-carboxylate

Guidance literature:: With sodium tetrahydroborate; nickel dichloride; In methanol; at 0 - 20 ℃;
DOI:10.1021/acs.jmedchem.9b01689

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1411994-27-8
C₂₁H₂₄N₂O₃

: 1411992-98-7
benzyl 5-((tert-butoxycarbonyl)aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-carboxylate

Guidance literature:: at 0 - 20 ℃;

Reference yield:

: 909072-54-4
2H-spiro[benzofuran-3,4′-piperidine]-5-carbonitrile

: 1411992-98-7
benzyl 5-((tert-butoxycarbonyl)aminomethyl)-2H-spiro[benzofuran-3,4′-piperidine]-1′-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 5 h / 0 - 20 °C

2: methanol; sodium tetrahydroborate; nickel dichloride / 0 - 20 °C

3: 0 - 20 °C

With methanol; sodium tetrahydroborate; sodium hydrogencarbonate; nickel dichloride; In tetrahydrofuran;