3-Phenyl-4-p-tolyl-1-oxa-2,4-diaza-spiro[4.6]undeca-2,6,8,10-tetraene

Base Information

• Chemical Name: 3-Phenyl-4-p-tolyl-1-oxa-2,4-diaza-spiro[4.6]undeca-2,6,8,10-tetraene
• CAS No.: 147196-11-0
• Molecular Formula: C₂₁H₁₈N₂O
• Molecular Weight: 314.387
• Mol file: 147196-11-0.mol

Synonyms:3-Phenyl-4-p-tolyl-1-oxa-2,4-diaza-spiro[4.6]undeca-2,6,8,10-tetraene

Chemical Property of 3-Phenyl-4-p-tolyl-1-oxa-2,4-diaza-spiro[4.6]undeca-2,6,8,10-tetraene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Phenyl-4-p-tolyl-1-oxa-2,4-diaza-spiro[4.6]undeca-2,6,8,10-tetraene

There total 2 articles about 3-Phenyl-4-p-tolyl-1-oxa-2,4-diaza-spiro[4.6]undeca-2,6,8,10-tetraene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzonitrile oxide (873-67-6) + N-cycloheptatrienylidene-4-methyl-aniline (949-68-8) → 3-Phenyl-4-p-tolyl-1-oxa-2,4-diaza-spiro[4.6]undeca-2,6,8,10-tetraene (147196-11-0)

Guidance literature:

for 0.5h; Ambient temperature; 1,3-dipolar cycloaddition reactions, other N-aryl-2,4,6-cycloheptatrien-1-imines and p-substituted benzonitrile oxides;

Reference yield:

N-cycloheptatrienylidene-4-methyl-aniline (949-68-8) + benzohydroximoyl chloride (698-16-8) → 3-Phenyl-4-p-tolyl-1-oxa-2,4-diaza-spiro[4.6]undeca-2,6,8,10-tetraene (147196-11-0) + 3-Phenyl-4-p-tolyl-4,9a-dihydro-1-oxa-2,4-diaza-benzocycloheptene

Guidance literature:

With triethylamine; In benzene; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.3987/COM-94-S50

Reference yield: 80.0%

3-Phenyl-4-p-tolyl-1-oxa-2,4-diaza-spiro[4.6]undeca-2,6,8,10-tetraene (147196-11-0) → Tropone (539-80-0) + N-(4-methylphenyl)-benzamide oxime (36954-50-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; water; for 1h; Ambient temperature;

DOI:10.1246/bcsj.68.3539

upstream raw materials:

benzonitrile oxide

N-cycloheptatrienylidene-4-methyl-aniline

benzohydroximoyl chloride

Downstream raw materials:

Tropone

N-(4-methylphenyl)-benzamide oxime