Technology Process of (S,E)-3-(4-(benzyloxy)but-2-enoyl)-4-phenyloxazolidin-2-one
There total 5 articles about (S,E)-3-(4-(benzyloxy)but-2-enoyl)-4-phenyloxazolidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(phenylmethoxy)-2-butenoic acid;
With
pivaloyl chloride; triethylamine;
In
tetrahydrofuran;
at -78 - 0 ℃;
(S)-4-phenyl-2-oxazolidinone;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 19h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / Cooling with ice
1.2: 4 h / 20 °C
2.1: diisobutylaluminium hydride / dichloromethane / 1.5 h / -78 °C
3.1: toluene / Reflux
4.1: lithium hydroxide; water / tetrahydrofuran / 3 h / 0 - 20 °C
5.1: triethylamine; pivaloyl chloride / tetrahydrofuran / -78 - 0 °C
5.2: 19 h / -78 - 20 °C / Inert atmosphere
With
water; pivaloyl chloride; sodium hydride; diisobutylaluminium hydride; triethylamine; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: diisobutylaluminium hydride / dichloromethane / 1.5 h / -78 °C
2.1: toluene / Reflux
3.1: lithium hydroxide; water / tetrahydrofuran / 3 h / 0 - 20 °C
4.1: triethylamine; pivaloyl chloride / tetrahydrofuran / -78 - 0 °C
4.2: 19 h / -78 - 20 °C / Inert atmosphere
With
water; pivaloyl chloride; diisobutylaluminium hydride; triethylamine; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; toluene;
