4-Bromoquinazoline

Base Information

• Chemical Name: 4-Bromoquinazoline
• CAS No.: 354574-59-7
• Molecular Formula: C₈H₅BrN₂
• Molecular Weight: 209.045
• Hs Code.: 2933990090
• Mol file: 354574-59-7.mol

Synonyms:4-bromoquinazoline

Chemical Property of 4-Bromoquinazoline

Chemical Property:

• Refractive Index: 1.685
• Boiling Point: 304.3 °C at 760 mmHg
• PKA: 0.85±0.30(Predicted)
• Flash Point: 137.8 °C
• PSA: 25.78000
• Density: 1.656g/cm³
• LogP: 2.39230
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromoquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromoquinazoline

There total 2 articles about 4-Bromoquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4-quinazolinol (491-36-1,134434-33-6) → 4-bromoquinazoline (354574-59-7)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In toluene; for 0.333333h; Reflux;

DOI:10.1016/j.tetlet.2011.11.123

Reference yield: 5.0%

4-Hydroxyquinazoline (491-36-1) → 4-bromoquinazoline (354574-59-7)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In 1,4-dioxane; for 1h; Heating;

DOI:10.1002/1522-2675(20010516)84:5<1112::AID-HLCA1112>3.0.CO;2-8

Reference yield:

4-bromoquinazoline (354574-59-7) + phenylboronic acid (98-80-6) → 4-phenylquinazoline (17629-01-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; at 100 ℃; Inert atmosphere;

upstream raw materials:

4-Hydroxyquinazoline

4-quinazolinol

Downstream raw materials:

4-phenylquinazoline

Refernces

• 1、 Sugimoto, Osamu,Mori, Miho,Moriya, Keisuke,Tanji, Ken-Ichi. "Application of phosphonium salts to the reactions of various kinds of amides". . p. 1112 - 1118. Retrieved 2007/10/03.