anhydro-1-hydroxy-5-methyl-3-oxo-2-phenyl-6,7,8,9-tetrahydropyrazolo<1,2-a>indazolium hydroxide

Base Information

• Chemical Name: anhydro-1-hydroxy-5-methyl-3-oxo-2-phenyl-6,7,8,9-tetrahydropyrazolo<1,2-a>indazolium hydroxide
• CAS No.: 79815-57-9
• Molecular Formula: C₁₇H₁₆N₂O₂
• Molecular Weight: 280.326
• Mol file: 79815-57-9.mol

Synonyms:anhydro-1-hydroxy-5-methyl-3-oxo-2-phenyl-6,7,8,9-tetrahydropyrazolo<1,2-a>indazolium hydroxide

Chemical Property of anhydro-1-hydroxy-5-methyl-3-oxo-2-phenyl-6,7,8,9-tetrahydropyrazolo<1,2-a>indazolium hydroxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of anhydro-1-hydroxy-5-methyl-3-oxo-2-phenyl-6,7,8,9-tetrahydropyrazolo<1,2-a>indazolium hydroxide

There total 3 articles about anhydro-1-hydroxy-5-methyl-3-oxo-2-phenyl-6,7,8,9-tetrahydropyrazolo<1,2-a>indazolium hydroxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-acetylcyclohexanone (874-23-7,125117-37-5) + 2-phenylmalonic acid dihydrazide (25457-59-4) → anhydro-1-hydroxy-5-methyl-3-oxo-2-phenyl-6,7,8,9-tetrahydropyrazolo<1,2-a>indazolium hydroxide (79815-57-9)

Guidance literature:

In ethanol; at 20 ℃; for 14h;

DOI:10.1002/jhet.5570420217

Reference yield: 43.0%

2-acetylcyclohexanone (874-23-7,125117-37-5) + 3,5-dihydroxy-4-phenylpyrazole (106367-54-8) → anhydro-1-hydroxy-5-methyl-3-oxo-2-phenyl-6,7,8,9-tetrahydropyrazolo<1,2-a>indazolium hydroxide (79815-57-9)

Guidance literature:

for 0.0833333h; Heating;

DOI:10.1021/jo00341a023

Reference yield:

diethyl 2-phenylmalonate (83-13-6) → anhydro-1-hydroxy-5-methyl-3-oxo-2-phenyl-6,7,8,9-tetrahydropyrazolo<1,2-a>indazolium hydroxide (79815-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / hydrazine hydrate / 1 h / Heating

2: 43 percent / 0.08 h / Heating

With hydrazine hydrate;

DOI:10.1021/jo00341a023

upstream raw materials:

2-acetylcyclohexanone

3,5-dihydroxy-4-phenylpyrazole

2-phenylmalonic acid dihydrazide

diethyl 2-phenylmalonate

Downstream raw materials:

α-phenylmalonmorpholide