3,5-dihydroxy-4-phenylpyrazole

Base Information

• Chemical Name: 3,5-dihydroxy-4-phenylpyrazole
• CAS No.: 106367-54-8
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.175
• Mol file: 106367-54-8.mol

Synonyms:3,5-dihydroxy-4-phenylpyrazole

Chemical Property of 3,5-dihydroxy-4-phenylpyrazole

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dihydroxy-4-phenylpyrazole

There total 2 articles about 3,5-dihydroxy-4-phenylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

diethyl 2-phenylmalonate (83-13-6) → 3,5-dihydroxy-4-phenylpyrazole (106367-54-8)

Guidance literature:

With hydrazine hydrate; for 1h; Heating;

DOI:10.1021/jo00341a023

Reference yield:

anhydro-1-hydroxy-3-oxo-2-phenylpyrazolo<1,2-a>pyrazolium hydroxide (75526-82-8) → Malondialdehyde (542-78-9) + 3,5-dihydroxy-4-phenylpyrazole (106367-54-8)

Guidance literature:

With morpholine; In water; acetonitrile; at 25 ℃; Rate constant;

DOI:10.1021/jo00341a023

Reference yield: 82.0%

malonaldehydebis(dimethylacetal) (102-52-3) + 3,5-dihydroxy-4-phenylpyrazole (106367-54-8) → anhydro-1-hydroxy-3-oxo-2-phenylpyrazolo<1,2-a>pyrazolium hydroxide (75526-82-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1021/jo00341a023

upstream raw materials:

anhydro-1-hydroxy-3-oxo-2-phenylpyrazolo<1,2-a>pyrazolium hydroxide

diethyl 2-phenylmalonate

Downstream raw materials:

3-phenyl-6,6-dipropyl-pyrazolo[5,1-b][1,3]oxazine-2,5,7-trione

3-Phenyl-1,2,6,7-tetrahydro-5H-pyrazolo<5,1-b><1,3>oxazin-6-spiro-1'-cyclopropan-2,5,7-trion

3'-phenyl-spiro[cyclobutane-1,6'-pyrazolo[5,1-b][1,3]oxazine]-2',5',7'-trione

6,6-diethyl-3-phenyl-pyrazolo[5,1-b][1,3]oxazine-2,5,7-trione

Refernces