(R)-3-[3,5-dibromo-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2-hydroxy-propionic acid methyl ester

Base Information

Chemical Name:(R)-3-[3,5-dibromo-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2-hydroxy-propionic acid methyl ester
CAS No.:866087-55-0
Molecular Formula:C₁₆H₂₄Br₂O₅Si
Molecular Weight:484.257
Hs Code.:

Synonyms:(R)-3-[3,5-dibromo-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2-hydroxy-propionic acid methyl ester

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Chemical Property of (R)-3-[3,5-dibromo-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2-hydroxy-propionic acid methyl ester

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Technology Process of (R)-3-[3,5-dibromo-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2-hydroxy-propionic acid methyl ester

There total 2 articles about (R)-3-[3,5-dibromo-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2-hydroxy-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 866087-55-0
(R)-3-[3,5-dibromo-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2-hydroxy-propionic acid methyl ester

Guidance literature:: (R)-3-(3,5-dibromo-4-hydroxy-phenyl)-2-hydroxy-propionic acid methyl ester; With 40% KF/Al₂O₃; In acetonitrile; at 20 ℃;

(2-trimethylethylsilylethoxy)methyl chloride; In acetonitrile; at 20 ℃; for 20h;

Reference yield: 59.0%

: 866087-54-9
(R)-3-(3,5-dibromo-4-hydroxy-phenyl)-2-hydroxy-propionic acid methyl ester

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 866087-55-0
(R)-3-[3,5-dibromo-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2-hydroxy-propionic acid methyl ester

Guidance literature:: (R)-3-(3,5-dibromo-4-hydroxy-phenyl)-2-hydroxy-propionic acid methyl ester; With 40% KF/Al₂O₃; In acetonitrile; at 20 ℃;

(2-trimethylethylsilylethoxy)methyl chloride; In acetonitrile; at 20 ℃; for 20h;

Reference yield: 69.0%

: 291509-61-0
3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

: 866087-55-0
(R)-3-[3,5-dibromo-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2-hydroxy-propionic acid methyl ester

: 7693-46-1
4-Nitrophenyl chloroformate

: 866087-56-1
4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-[3,5-dibromo-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-1-methoxycarbonyl-ethyl ester

Guidance literature:: 4-Nitrophenyl chloroformate; With dmap; In acetonitrile; at -7 - 15 ℃;

(R)-3-[3,5-dibromo-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2-hydroxy-propionic acid methyl ester; In acetonitrile; at -7 ℃; for 0.25h;

3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one; In acetonitrile; at -7 - 20 ℃; for 2.5h;